DRD2 TaqIA polymorphism is associated with urinary homovanillic acid levels in a sample of spanish male alcoholic patients
- 55 Downloads
TheTaqIA1 allele of the dopamine receptor gene D2 (DRD2) has been associated with alcoholism, as well as with other addictive behaviours. The exact nature of how the presence of this allele can be a vulnerability factor in the development of alcoholism remains unclear. In this study we found that the presence in theDRD2 genotype of theTaqIA1 allele in Spanish alcoholics is associated with higher levels of urine homovanillic acid (HVA) when compared to patients homozygous for theTaqIA2 allele.
A sample of 142 Spanish male alcoholic patients was split into 2 groups on the basis of the presence or absence of the A1 allele in their genotype. The urine sample was analyzed by high performance liquid cromatography (HPLC), and the concentration of homovanillic acid (HVA), 5-hydroxyin-doleacetic acid (5-HIAA) and vanilylmandelic acid (VMA) was determined. We found a statistical difference in the concentration of HVA between the groups, that suggests this polymorphism could be related to the variance of urine HVA levels.
KeywordsAlcoholism DRD2 homovanillic acid (HVA) TaqIA polymorphism
Unable to display preview. Download preview PDF.
- Babor TF, M Hofmann, FK DelBoca, V Hesselbrock, RE Meyer, ZS Dolinsky and B Rounsaville (1992) Types of alcoholics: I.Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch. Gen. Psychiatry 49, 599–608.Google Scholar
- Gabbay FH, CC Duncan, G Bird, GR Uhl and AF Mirsky (1996) D2 dopamine receptor Ta q 1A genotypic differences in event-related brain potentials, In Problems of Drug Dependence 1995 (Harris LS, Ed.) (NIDA Research Monograph 162: Rockville, MD, USA), p 129.Google Scholar
- Goldman D, M Dean, GL Brown, AM Bolos, R Tokola, M Virkkunen and M Linnoila (1992) D2 dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5- hydroxyin-doleacetic acid and 3-methoxy-4-hydroxyphenylglycol in alcoholics in Finland and the United States.Acta Psychiatr. Scand. 86, 351–357.PubMedCrossRefGoogle Scholar
- Goodwin DW (1985) Genetic Determinants of Alcoholism (McGraw Hill: New York) pp 55–70.Google Scholar
- Thompson J, N Thomas, A Singleton, M Piggott, S Lloyd, EK Perry, CM Morris, RH Perry, IN Ferrier and JA Court (1997) D2 dopamine receptor gene (DRD2) Ta q IA polymorphism, reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele.Pharmacogenetics 7, 479–484.PubMedCrossRefGoogle Scholar