Journal of Plant Biology

, Volume 50, Issue 3, pp 274–281 | Cite as

Signaling network for stem cell maintenance and functioning inarabidopsis shoot apical meristem

  • Cha Young Kim
  • Lin Liu
  • Jae-Yean Kim


The shoot apical meristem (SAM) domain, which contains a self-renewing population of undifferentiated pluripotent cells, produces all of a plant’s post-embryonic aerial organs. Intra- and intercellular signaling networks are essential to the maintenance of SAM size and structure, and for coordinating the formation and patterning of new organs. A key regulatory system for meristem functioning consists of a non-cell-autonomous WUSCHEL (WUS)-CLAVATA (CLV) regulatory loop and class I KNOX-related signaling in the shoot apex. Meristem activity is also dependent on short- and long-distance signaling from the organizing center, organ boundaries/primordia, and distant organs. Here, we provide an overview of SAM organization and present our current knowledge about the signaling network for stem cell maintenance and functioning in the vegetative SAM in Arabidopsis. Transcription factors belonging to the WOX, KNOX, HD-ZIP, MYB, SAND, AP2, and NAC domain protein families, as well as microRNA, play central roles in this network, along with hormonal cross-talk. We also discuss regulation at different levels, such as for protein interactions, and transcriptional and epigenetic controls. Our intent is to show how various signals are integrated to maintain a stem cell niche in the SAM.


Clavata epigenetic regulation plasmodesmata shoot meristem signaling SHOOT Meristemless Wuschel 









KN1-related homeobox




shoot apical meristem






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Copyright information

© The Botanical Society of Korea 2007

Authors and Affiliations

  1. 1.Division of Applied Life Science, Plant Molecular Biology and Biotechnology Center, Environmental Biotechnology National Research Core CenterGraduate School of Gyeongsang National UniversityJinjuKorea

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