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Biochemical studies of apparently ‘healthy’ blood donors with reference to liver function tests and immunoglobulins

  • Alexius C. J. Ezeoke
Original Contributions
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Summary

Liver function tests and immunoglobulin features of apparently ‘healthy’ blood donors were studied. Twenty-one (9.5%) subjects with HBsAg were observed. These subjects were found to have significantly higher mean and standard deviation of total serum bilirubin, alanine and aspartate aminotransferase levels than those of a randomly selected HBsAg-negative group. Serum urea was significantly lower (p < 0.01) in the HBsAg-positive cases. Total serum IgE (IU/ml) was significantly higher in the HBsAg-positive cases (p < 0.01). Comparison of laboratory findings of these cases and active hepatitis HBsAg-positive subjects showed that there were more elevated abnormalities in the latter.

Key-words

Blood transfusion Hepatitis B surface antigen Immunoglobulins Liver function tests 

References

  1. 1.
    Bell J. L., Baron D. N.: A colorimetric method for the determination of isocitric dehydrogenase — Clin. chim. Acta5, 740, 1960.CrossRefGoogle Scholar
  2. 2.
    Bird G. W. G., Menon K. K.: Survival ofMicrofilaria bancrofti in stored blood — LancetII, 721, 1961.CrossRefGoogle Scholar
  3. 3.
    Bousness R. W., Tausaky H. H.: Determination of serum and urine creatinine — J. biol. Chem.158, 581, 1945.Google Scholar
  4. 4.
    Ferris H. E., Alpert S., Coakley C. S.: Prevention of allergic transfusion reactions — Amer. Practit.3, 177, 1952.Google Scholar
  5. 5.
    Frankel D. B., Weidner N.: Use of Chlortrimeton maleate injectable in blood transfusions. — Ann. Allergyii, 204, 1953.Google Scholar
  6. 6.
    King P. R. N., King E. J.: Estimation of a plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine — J. clin. Pathol.7, 322, 1954.PubMedCrossRefGoogle Scholar
  7. 7.
    Klatskin G.: Persistent HB antigenemia-associated clinical manifestations and hepatic lesions — Amer. J. med. Sci.270, 33, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Moore C. V.: Iron metabolism and hypochromic anaemia. Nutritional anaemia. Robert Could Research Foundation, Cincinnati, USA, 1948.Google Scholar
  9. 9.
    Nabarro D., Edmond D. G.: Accidental transmission of malaria to a child by the injection of blood — Lancetii, 556, 1940.Google Scholar
  10. 10.
    Natelson S.: Microtechniques of clinical chemistry for the routine laboratory. C. C. Thomas, Springfield, Ill., 1957; p. 381.Google Scholar
  11. 11.
    Okafor G. O., Obi G. O.: The incidence of hepatitis B surface antigen in Nigeria — Trans. roy. Soc. trop. Med. Hyg.73, 648, 1979.PubMedCrossRefGoogle Scholar
  12. 12.
    Powell W. N.: Determination of total and conjugated serum bilirubin. — Amer. J. clin. Pathol.29, 412, 1958.Google Scholar
  13. 13.
    Ravitch M. M., Farmer T. W., Davis B.: Use of blood donors with positive serologic tests for syphilis — With a note on the disappearance of passively transferred reagin. — J. clin. Invest.28, 18, 1949.CrossRefGoogle Scholar
  14. 14.
    Reitman S., Frankel S.: A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase — Amer. J. clin. Pathol.28, 56, 1957.Google Scholar
  15. 15.
    Sharpey-Schafer E. P., Wallace J.: Retention of injected serum in the circulation — Lanceti, 699, 1942.CrossRefGoogle Scholar
  16. 16.
    Siegel S. E., Lunde M. N., Gellerman A. H., Halterman R. H., Brown J. A., Levine S. A., Graw R. G. Jr.: Transmission of toxoplasmosis by leukocyte transfusion. — Blood37, 388, 1971.PubMedGoogle Scholar
  17. 17.
    Simon S. W., Eckman W. G.: Use of Chlortrimeton in the prevention of blood transfusion reactions — Ann. Allergy12, 182, 1954.PubMedGoogle Scholar
  18. 18.
    Solem J. H., Jorgensen W.: Accidentally transmitted infections of mononucleosis — Acta med, scand.186, 433, 1969.Google Scholar
  19. 19.
    Stephen C.: Untersuchungen über die Verwendung der antihuman Globulin-Ablenkungsmethode zum Nachweis von Thrombozytenantikörpern — Wien. Z. inn. Med.36, 246, 1955.Google Scholar
  20. 20.
    Szmuness W., Harley E. J., Prince A. M.: Intrafamilial spread of asymptomatic hepatitis B — Amer. J. med. Sci.270, 293, 1975.PubMedCrossRefGoogle Scholar
  21. 21.
    Varley H.: Biuret method in practical clinical biochemistry. 4th ed., W. Heinemann Medical Books, London, 1969; p. 245.Google Scholar
  22. 22.
    Vilaseca J. A., Cerisola J. A., Olarte J. A., Zothner A.: The use of crystal violet in the prevention of the transmission of Chagas-Mazza disease (South American trypanosomiasis) — Vox Sang. (Basel)11, 711, 1966.Google Scholar
  23. 23.
    Weller I.: Acquired immunodeficiency syndrome (AIDS) — Postgrad. Doct.6, 220, 1984.Google Scholar
  24. 24.
    WHO: Chemotherapy of malaria — Monogr. WHO techn. Rep. Ser. no. 27, 1955.Google Scholar
  25. 25.
    WHO: WHO Expert Committee on Hepatitis — WHO techn. Rep. Ser. no. 285, 1964.Google Scholar
  26. 26.
    WHO: Advances in viral hepatitis — WHO techn. Rep. Ser. no. 602, 1977.Google Scholar
  27. 27.
    Wood E. E.: Brucellosis as a hazard of blood transfusion — Brit. med. J.i, 27, 1955.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Alexius C. J. Ezeoke
    • 1
  1. 1.Department of Chemical PathologyUniversity of Nigeria Teaching Hospital (UNTH)Enugu, Anambra StateNigeria

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