Ricerca in clinica e in laboratorio

, Volume 15, Issue 4, pp 343–347 | Cite as

Trypsin/creatinine clearance ratio and serum immunoreactive trypsin in digestive and pancreatic diseases

  • Giuseppe Del Favero
  • Carlo Fabris
  • Piero Bonvicini
  • Antonio Piccoli
  • Ugo Baccaglini
  • Sergio Pedrazzoli
  • Angelo Burlina
  • Remo Naccarato
Original Contributions


The behavior of trypsin/creatinine clearance ratio (Ctr/Ccr) and serum immunoreactive trypsin (IRT) was evaluated in a total of 168 subjects with pancreatic cancer, chronic pancreatitis and non-pancreatic digestive diseases. Amylase/creatinine clearance ratio (Cam/Ccr) and serum amylase levels were also evaluated in order to establish their possible relationship with Ctr/Ccr and IRT values. Elevated Ctr/Ccr and IRT values were observed in several patients with pancreatic cancer and chronic pancreatitis. Abnormal IRT and Ctr/Ccr values were found in 28.2 and 4% of non-pancreatic digestive diseases, respectively. IRT and amylase serum levels showed consensual modifications, while Ctr/Ccr showed a behavior different from that of Cam/Ccr. Liver damage seems to play a role in increasing serum IRT levels of patients without pancreatic involvement, while the increased Ctr/Ccr seems to depend on other factors, for instance renal tubular dysfunction.


Amylase Chronic pancreatitis Digestive diseases Pancreatic cancer Trypsin Urinary excretion 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Giuseppe Del Favero
    • 1
  • Carlo Fabris
    • 1
  • Piero Bonvicini
    • 3
  • Antonio Piccoli
    • 1
  • Ugo Baccaglini
    • 2
  • Sergio Pedrazzoli
    • 2
  • Angelo Burlina
    • 3
  • Remo Naccarato
    • 1
  1. 1.Cattedra di Malattie dell’Apparato Digerente Istituto di Medicina InternaPoliclinico UniversitarioPadovaItalia
  2. 2.Istituto di Clinical Chirurgica IUniversità degli Studi di 3 PadovaItaly
  3. 3.Laboratorio di Chimica e Microscopia ClinicaOspedale Civile di PadovaItaly

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