Summary
The behavior of trypsin/creatinine clearance ratio (Ctr/Ccr) and serum immunoreactive trypsin (IRT) was evaluated in a total of 168 subjects with pancreatic cancer, chronic pancreatitis and non-pancreatic digestive diseases. Amylase/creatinine clearance ratio (Cam/Ccr) and serum amylase levels were also evaluated in order to establish their possible relationship with Ctr/Ccr and IRT values. Elevated Ctr/Ccr and IRT values were observed in several patients with pancreatic cancer and chronic pancreatitis. Abnormal IRT and Ctr/Ccr values were found in 28.2 and 4% of non-pancreatic digestive diseases, respectively. IRT and amylase serum levels showed consensual modifications, while Ctr/Ccr showed a behavior different from that of Cam/Ccr. Liver damage seems to play a role in increasing serum IRT levels of patients without pancreatic involvement, while the increased Ctr/Ccr seems to depend on other factors, for instance renal tubular dysfunction.
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This work was partially supported by grants from theMinistero della Pubblica Istruzione, Roma, Italy, and fromCentro Regionale di Alta Specializzazione per lo Studio delle Malattie del Fegato e del Pancreas. Under the auspices of the ‘R. Farini Foundation for Gastroenterology Research’.
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Del Favero, G., Fabris, C., Bonvicini, P. et al. Trypsin/creatinine clearance ratio and serum immunoreactive trypsin in digestive and pancreatic diseases. La Ricerca in Clin. Lab. 15, 343–347 (1985). https://doi.org/10.1007/BF03029149
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DOI: https://doi.org/10.1007/BF03029149