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The Italian Journal of Neurological Sciences

, Volume 19, Issue 1, pp 49–52 | Cite as

The contribution of Gaetano Perusini to the definition of Alzheimer’s disease

  • B. Lucci
History of Neurology

Abstracts

This paper seeks to examine Perusini’s scientific contribution to Alzheimer’s disease, on the basis of critical reading of the three fundamental papers he produced between 1906 and 1911, and published between 1909 and 1911.

The examination of three publications clearly shows that, after Alzheimer’s concise clinical report of 3 November 1906, Perusini was responsible for more clearly defining its clinical and histopatological characteristics without ever claiming be the discoverer of the new disease.

The paper also describes Alzheimer’s express wish to entrust the investigation of the disease to Perusini, and the brilliant manner in which this was achivied.

The on-going debate on the difference between senile and presenile dementia, which was originally raised by Kraepelin’s distinction of the two forms, is also discussed.

Key words

Gaetano Perusini History of Alzheimer’s disease 

Sommario

Il lavoro vuole esaminare il contribute scientifico che Gaetano Perusini ha dato alla demenza di Alzheimer, sulla base della rilettura critica dei tre fondamentali lavori del Perusini elaborati fra il 1906 e il 1911 e pubblicati dal 1909 al 1911

Dall’ esame delle tre pubblicazioni emerge chiaramente che, dopo la succinta segnalazione del caso clinico di Alzheimer del 3 Novembre 1906, la più completa definizione clinica e istopatologica della malattia si deve al Perusini, senza che egli si esponga come scopritore della nuova malattia.

Si esamina anche la precisa volontà di Alzheimer di affidare al Perusini l’approfondimento del problema che Perusini assolve brillantemente.

Viene anche affrontato il dibattito, tuttora in corso sulla distinzione fra demenza senile e presenile che fu risolta da Kraepelin a suo tempo con la distinzione fra le due forme.

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Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • B. Lucci
    • 1
  1. 1.Department of NeurologyHospital of PordenonePordenoneItaly

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