, Volume 30, Issue 6, pp 353–358 | Cite as

Neurophysiological mechanisms of neurological disorders in people irradiated in the Chernobyl’ catastrophe

  • E. A. Vashchenko
  • A. I. Nyagu
  • B. A. Brous


We analyzed shifts in the functional parameters of the autonomic and segmental somatic reflex mechanisms in various categories of people subjected to irradiation because of the catastrophe at the Chernobyl’ NPS. It is demonstrated that long-lasting irradiation even with mild intensity evokes serious damage to the central structures controlling autonomic functions (first of all, the hypothalamus). This results in the development of autonomic dysfunction with domination of disorders of the sympathetic system manifested in a dramatic drop in the amplitude, an increase in the duration, and modification of the phase structure of evoked autonomic skin responses in all examined groups of persons. Cardiovascular and neurotrophic disorders are crucial factors, which determine pathological modifications in the somatic reflex sphere (a drop in the amplitude of sensory evoked potentials and a decrease of the conduction velocity in the peripheral nerves, a drop in the amplitude of M responses in the limb muscles, but with relatively small shifts in the synaptic relays of segmental reflex arcs).


Nuclear Power Station Evoke Potential Skin Sympathetic Response Sensory Evoke Potential Pathological Modification 
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  1. 1.
    Mental Health Consequences of the Chernobyl Disaster. Current State and Future Prospects, Proceedings of International Conference, Khreshchatyk, Kyiv (1995).Google Scholar
  2. 2.
    International Conference on Health Consequences of the Chernobyl and Other Radiological Accidents, WHO, Geneva (1995).Google Scholar
  3. 3.
    International Conference “One Decade after Chernobyl,” Book of Extended Synopses, IAEA, Vienna (1996).Google Scholar
  4. 4.
    International Conference on Radiation and Health, Beer Sheva, Israel (1996).Google Scholar
  5. 5.
    NATO Advanced Research Workshop on Ocular Radiation Risk Assessment in Populations Exposed to Environmental Radiation Contamination, Kyiv (1997).Google Scholar
  6. 6.
    2nd International Conference “Long-Term Health Consequences of the Chernobyl Disaster,” Kyiv (1998).Google Scholar
  7. 7.
    A book review by A. K. Gus’kova, V. G. Lelyuk, and T. G. Protasova,Afterirradiation Encephalopathy: Experimental Studies and Clinical Observations, A. P. Romodanov (ed.), Kyiv (1993),Med. Radiologiya Radiats. Bezopasnost’,41, No. 3, 70–73 (1996).Google Scholar
  8. 8.
    A. K. Gus’kova, “Ten years after the ChNPS catastrophe (a retrospective of clinical events and measures for corrections of the consequences),”Med. Radiologiya Radiats. Bezopasnost’,42, No. 1, 5–12 (1997).Google Scholar
  9. 9.
    F. S. Torubarov, “Results and tasks of clinical studies in radiational neurology,”Med. Radiologiya, No. 8, 29–31 (1991).Google Scholar
  10. 10.
    E. A. Vashchenko, A. I. Nyagu, B. A. Brous, and D. A. Vasilenko, “State of the Somatic Segmental Reflex Mechanisms in Humans Subjected to Irradiation in the Chernobyl’ Nuclear Catastrophe,”Neirofiziologiya/Neurophysiology,29, No. 2, 83–92 (1998).CrossRefGoogle Scholar
  11. 11.
    E. A. Vashchenko, A. I. Nyagu, B. A. Brous, and D. A. Vasilenko, “State of the Autonomic Reflex Mechanisms in Humans Subjected to Irradiation in the Chernobyl’ Catastrophe,”Neirofiziologiya/Neurophysiology,30, No. 1, 1–13 (1998).CrossRefGoogle Scholar
  12. 12.
    W. Janig and H. Kummel, “Functional discrimination of post-ganglionic neurones to the cat’s hindpaw with respect to the skin potentials recorded from the hairless skin,”Pflugers Arch.,371, 217–225 (1977).PubMedCrossRefGoogle Scholar
  13. 13.
    W. Janig, G. Sundlof, and B. G. Wallin, “Discharge patterns of sympathetic neurons supplying skeletal muscle and skin in man and cat,”J. Auton. Nerv. Syst., No. 7, 239–257 (1983).Google Scholar
  14. 14.
    V. I. Skok and A. Ya. Ivanov,Natural Activity of the Autonomic Ganglia (in Russian), Naukova Dumka, Kyiv (1989).Google Scholar
  15. 15.
    A. M. Vein and A. B. Danilov, “Diagnostic importance of a cutaneous sympathetic potential,”Zh. Nevropatologii Psykhiatrii,92, No. 5, 3–7 (1992).Google Scholar
  16. 16.
    A. Mikhailenko, M. M. Odyinak, Yu. S. Ivanov, et al., “Regularities in modifications of evoked cutaneous autonomic potential in diseases of the nervous system,”Zh. Nevropatol. Psykhiatrii,97, No. 4, 58–61 (1997).Google Scholar
  17. 17.
    H. Bostock, D. Burke, and J. P. Hales, “Differences in behaviour of sensory and motor axons following release of ischaemia,”Brain,117, No. 2, 225–234 (1994).PubMedCrossRefGoogle Scholar
  18. 18.
    D. L. Hammond and T. L. Yaksh, “Peripheral and central pathways in pain,”Pharmacol Ther.,14, No. 3, 459–475 (1981).PubMedCrossRefGoogle Scholar
  19. 19.
    Yu. P. Limanskii,Physiology of Pain [in Russian], Zdorov’ya, Kyiv (1981).Google Scholar
  20. 20.
    J. Verdugo, M. Campero, and J. Ochoa, “Phentolamine sympathetic block in painful polyneuropathies. Further questioning of the concept of sympathetically maintained pain,”Neurology,44, No. 6, 1010–1014 (1994).PubMedGoogle Scholar
  21. 21.
    V. A. Baraboi and D. A. Sutkovoi, “Indices of oxidative metabolism in brain tissue of rats: the effects of acute low-dose radiational influences,”Neirofiziologiya/Neurophysiology,27, No. 2, 93–99 (1995).Google Scholar
  22. 22.
    L. M. Ovsyannikova, S. M. Alyokhina, A. F. Protas, et al., “Role of activation of the processes of lipid peroxidation in pathogenesis of psychosomatic diseases in person subjected to Chernobyl’ catastrophe-related factors,” in:Mental Health Consequences of the Chernobyl Disaster. Current State and Future Prospects (Proceedings of the International Conference) [in Russian], Khreshchatyk, Kyiv (1995), p. 60.Google Scholar
  23. 23.
    D. A. Sutkovoi, B. A. Baraboi, and S. A. Oleinik, “Metabolism in rat brain tissues: effects of prolonged low-dose x-ray irradiation,”Neirofiziologiya/Neurophysiology,27, No. 4, 243–252 (1995).Google Scholar
  24. 24.
    L. A. Gromov,Neuropeptides [in Russian], Zdorov’ya, Kyiv (1992).Google Scholar
  25. 25.
    L. I. Lyasko, G. N. Sushkevich, A. F. Tsyb, et al., “Dynamics of the contents of hypophyseal hormones, neuropeptides, and neurotransmitters in people directly involved in the cleanup and repair after the catastrophe. An attempt to correct with chlorella E-21,”Med. Radiologiya Radiats. Bezopasnosi’,39, No. 4, 22–25 (1994).Google Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • E. A. Vashchenko
    • 1
  • A. I. Nyagu
    • 1
  • B. A. Brous
    • 1
  1. 1.Scientific Center for Radiation MedicineAcademy of Medical Sciences of UkraineKyivUkraine

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