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Canadian Anaesthetists’ Society Journal

, Volume 20, Issue 5, pp 709–712 | Cite as

Prolongation of morphine anaesthesia in a patient with Gilbert's disease: Report of a case

  • Tad G. Nishimura
  • Stephen H. Jackson
  • Stanley N. Cohen
Article

Summary

The case is presented of a patient with Gilbert's Disease who received a predominantly morphine anaesthetic for cardiac surgery. He was excessively obtunded in the post-operative period. It is postulated that the defect responsible for the inadequate bilirubin conjugation which is characteristic of Gilbert's Disease may also

Keywords

Morphine Morphine Sulfate Cephaloridine Scleral Icterus Morphine Glucuronide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Nous présentons le cas d'un malade souffrant de la maladie de Gilbert qui a reçu, pour de la chirurgie cardiaque, une forte dose de morphine comme anaesthésique. Au cours des suites opératoires, il a été grandement obnubilé. L'on présume que la pathologie responsable pour la conjugaison inadéquate de la bilirubin qui caractérise la maladie de Gilbert peut bien également être responsable de l'effet prolongé de la morphine puisque les deux substances sont probablement métabolisées de la même façon par conjugaison dans le foie.

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Copyright information

© Canadian Anesthesiologists 1973

Authors and Affiliations

  • Tad G. Nishimura
    • 1
  • Stephen H. Jackson
    • 1
  • Stanley N. Cohen
    • 1
  1. 1.Departments of Anesthesia and MedicineStanford University School of MedicineStanford

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