Canadian Anaesthetists’ Society Journal

, Volume 18, Issue 3, pp 298–303 | Cite as

Effects of droperidol-pentazocine-N2O anaesthesia on adrenocortical function in man

  • T. Oyama
  • M. Takiguchi
  • K. Sato

Summary and Conclusion

A study was undertaken to evaluate the effect of neuroleptanaesthesia (nla), produced by droperidol-pentazocine-nitrous oxide on adrenocortical function, as judged by its influence on plasma free cortisol levels in 19 patients undergoing operation.

nla alone for 45 minutes stimulated adrenocortical function significantly. Adrenocortical stimulation was further accentuated during surgery and in the postoperative period. A possible relationship between the tendency to arterial hypertension caused by droperidol-pentazocine-nitrous oxide and adrenocortical activity is also discussed.


Nitrous Oxide Pethidine Droperidol Nous Avons Pentazocine 
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Cette étude voulait évaluer les effets de la neuroleptanesthésie (nla) sur la fonction corticosurrénalienne; la neuroleptanesthésie (nla) était produite par l'association droperidol-pentazocine et protoxyde d'azote; pour ce faire, nous avons étudié chez 19 opérés, l'influence de lanla sur les taux de cortisol plasmatique libre.

Durant 45 minutes, lanla, agissant seule, a stimulé la fonction corticoscurrénalienne de façon significative; au cours de l'opération et des suites opératoires, nous avons constaté une stimulation additionnelle de la cortico-surrénale. Nous avons également discuté la relation possible entre la tendance à l'augmentation de la tension artérielle causée par l'association dropéridol-pentozocine et protoxyde d'azote et l'activité cortico-surrénalienne.


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Copyright information

© Canadian Anesthesiologists 1971

Authors and Affiliations

  • T. Oyama
    • 1
  • M. Takiguchi
    • 1
  • K. Sato
    • 1
  1. 1.Department of AnaesthesiaHirosaki University School of MedicineHirosaki, Aomori-KenJapan

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