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Canadian Anaesthetists’ Society Journal

, Volume 18, Issue 3, pp 298–303 | Cite as

Effects of droperidol-pentazocine-N2O anaesthesia on adrenocortical function in man

  • T. Oyama
  • M. Takiguchi
  • K. Sato
Article

Summary and Conclusion

A study was undertaken to evaluate the effect of neuroleptanaesthesia (nla), produced by droperidol-pentazocine-nitrous oxide on adrenocortical function, as judged by its influence on plasma free cortisol levels in 19 patients undergoing operation.

nla alone for 45 minutes stimulated adrenocortical function significantly. Adrenocortical stimulation was further accentuated during surgery and in the postoperative period. A possible relationship between the tendency to arterial hypertension caused by droperidol-pentazocine-nitrous oxide and adrenocortical activity is also discussed.

Keywords

Nitrous Oxide Pethidine Droperidol Nous Avons Pentazocine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Cette étude voulait évaluer les effets de la neuroleptanesthésie (nla) sur la fonction corticosurrénalienne; la neuroleptanesthésie (nla) était produite par l'association droperidol-pentazocine et protoxyde d'azote; pour ce faire, nous avons étudié chez 19 opérés, l'influence de lanla sur les taux de cortisol plasmatique libre.

Durant 45 minutes, lanla, agissant seule, a stimulé la fonction corticoscurrénalienne de façon significative; au cours de l'opération et des suites opératoires, nous avons constaté une stimulation additionnelle de la cortico-surrénale. Nous avons également discuté la relation possible entre la tendance à l'augmentation de la tension artérielle causée par l'association dropéridol-pentozocine et protoxyde d'azote et l'activité cortico-surrénalienne.

References

  1. 1.
    Oyama, T. &Takiguchi, M.. Effect of Neuroleptanaesthesia on Adrenocortical Function in Man. Brit. J. Anaesth.42: 425 (1970).PubMedCrossRefGoogle Scholar
  2. 2.
    Corssen, G.;Domino, E. F.; &Sweet, R. B.. Neuroleptanalgesia and Anaesthesia. Anesth. & Analg.43: 748 (1964).Google Scholar
  3. 3.
    Zauder, H. L.;Del Guercio, L. R. M.;Feins, N.;Barton, N.; &Wollman, S. Hemodynamics during Neurolept Analgesia. Anesthessiology.26: 266 (1965).CrossRefGoogle Scholar
  4. 4.
    Sadove, M.;Balagot, R. C.; &Pecora, F. N.. Pentazocine—A New Nonaddicting Analgesis. Preliminary Single-Blind Study. J.A.M.A.189 199 (1964).PubMedGoogle Scholar
  5. 5.
    Norris, W. &Telfer, A. B. M.. The Sedative Properties of Pentazocine (Fortral). Brit. J. Anaesth.40: 341 (1968).PubMedCrossRefGoogle Scholar
  6. 6.
    Murphy, B. E. P.. Some Studies of the Protein-Binding of Steroids and Their Application to the Routine Micro and Ultramicro Measurement of Various Steroids in the Body Fluids by Competitive Protein-Binding Radioassay. J. Clin. Endocr. & Met.27: 973 (1967).Google Scholar
  7. 7.
    Oyama, T.;Takiguchi, M.;Takazama, T.; &Kimura, K.. Effect of Meperidine on Adrenocortical Function in Man. Canad. Anaesth. Soc. J.16: 282 (1969).PubMedCrossRefGoogle Scholar
  8. 8.
    Vandam, L. D. &Moore, F. D. Adrenocortical Mechanism Related to Anesthesia. Anesthesiology.21: 531 (1960).PubMedCrossRefGoogle Scholar
  9. 9.
    Oyama, T.;Matsumoto, F.; &Kudo, T.. Effects of Ketamine on Adrenocortical Function in Man. Anesth. Analg.49: 697 (1970).PubMedGoogle Scholar
  10. 10.
    Oyama, T.;Kudo, T.;Shibata, S.; &Matsumoto, F.. Effects of Gamma-Hydroxybutyrate on Plasma Hydrocortisone Conentration in Man. Anesth. & Analg.47: 350 (1968).CrossRefGoogle Scholar
  11. 11.
    Oyama, T.;Kimura, K.;Takazawa, T.; &Takiguchi, M.. Effect of Propanidid on Plasma Cortisol Concentration in Man. Anesth. & Analg.49: 39 (1970).Google Scholar
  12. 12.
    Willson, R. F. &Fisher, R. R.. The Hemodynamic Effects of Massive Steroids in Clinical Shock. Surg. Gynec. Obstet.127: 769 (1968).Google Scholar
  13. 13.
    Thomas, C. S. &Brockman, S. K.. The Role of Adrenal Corticosteroid Therapy in Eschericha Coli Endotoxin Shock. Surg. Gynec. Obstet.126: 61 (1968).PubMedGoogle Scholar
  14. 14.
    Spink, W. W. &Vick, J. A.. Evaluation of Plasma, Metaraminol and Hydrocortisone in Experimental Shock. Circ. Res.9 184 (1961).Google Scholar
  15. 15.
    Lillehei, R. C.;Longerbeam, J. K.;Block, J. H.; &Manax, W. G.. The Nature of Irreversible Shock, Experimental and Clinical Observations. Ann. Surg.160: 682 (1964).PubMedCrossRefGoogle Scholar
  16. 16.
    Schumer, W. &Sperling, R.. Shock and Its Effects on the Cell. J.A.M.A.205: 215 (1968).PubMedCrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1971

Authors and Affiliations

  • T. Oyama
    • 1
  • M. Takiguchi
    • 1
  • K. Sato
    • 1
  1. 1.Department of AnaesthesiaHirosaki University School of MedicineHirosaki, Aomori-KenJapan

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