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Canadian Anaesthetists’ Society Journal

, Volume 18, Issue 1, pp 84–91 | Cite as

Anaesthetic time/dose curves. VII. Experience with Pentazocine

  • G. R. Gerula
  • Keeri-Szanto
Article

Summary

Rigidly standardised nitrous oxide relaxant anaesthesia was supplemented in 41 subjects by 0.1 mg per kg increments of intravenous Pentazocine for a variety of extensive major operations. Satisfactory anaesthesia was achieved in 39 patients. Individual anaesthetic time/dose curves were recorded for each patient: these revealed a sharp division into a high- and low-consumption group. Comparison of the mean time/dose curve with similar curves obtained earlier for other drugs, indicated that Pentazocine was at least twice as potent as Meperidine in this application.

Blood gas studies conducted one hour after the end of surgery showed that in the presence of pain, judicious doses of Pentazocine will provide adequate analgesia without respiratory depression even in poor-risk individuals.

Keywords

NASH Respiratory Depression Meperidine Nous Avons Pentazocine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Au cours d’une variété d’opérations extensives majeures, nous avons complété une anesthésie au protoxyde d’azote et myorésolutifs chez 41 sujets avec de la Pentazocine par voie endoveineuse à la dose 0.1 mg/kilo. Nous avons obtenu une anesthésie satisfaisante chez 39 malades. Pour chacun des malades, nous avons fait une courbe anesthésique individuelle durée/dose: ces courbes ont établi une division marquée entre un groupe à haute consommation et un groupe à basse consommation. Dans cette application spécifique, la comparaison de la courbe moyenne durée/dose avec des courbes similaires obtenues antérieurement avec d’autres médicaments, laisse croire que la Pentazocine était au moins deux fois plus puissante que la mépéridine. Des études des gaz sanguins pratiquées une heure après la fin de la chirurgie ont montré que, chez le malade souffrant, des doses judicieuses de Pentazocine vont procurer une analgésie adéquate sans dépression respiratoire mème chez les mauvais risques.

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Copyright information

© Canadian Anesthesiologists 1971

Authors and Affiliations

  • G. R. Gerula
    • 1
  • Keeri-Szanto
    • 1
  1. 1.University of Western OntarioOntarioCanada

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