The effect of several leukemia therapeutic drugs on the calcium equilibrium within the K562 cells
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The Daunomycin, Cyclophosphamide, Cytarabine Hydrochloride and Vincristine Sulfale all are the drugs used in the therapy of leukemia. When the leukemia cell line, K562, were treated by themin vitro, a sharp decrease of intracellular free Ca2+ concentration could be found. The anti-cancer mechanisms of these drugs are inhibiting the DNA or RNA syntheses and interrupting the mitoses of tumor cells. Our experiment suggested that beside the above behaviors, these anti-cancer drugs can also suppress the function of tumor cells by means of decreasing their intracellular Ca2+ levels.
Key wordsDaunomycin Cyclophospamide Cytarabine Hydrochloride, Vincristine sulfale, Leukemia, Ca2+
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