Advertisement

Chinese Journal of Cancer Research

, Volume 5, Issue 4, pp 289–292 | Cite as

The effect of several leukemia therapeutic drugs on the calcium equilibrium within the K562 cells

  • Lu Chengrong 
  • Liu Yaning 
  • Wang Hui 
Clinical Observation
  • 16 Downloads

Abstract

The Daunomycin, Cyclophosphamide, Cytarabine Hydrochloride and Vincristine Sulfale all are the drugs used in the therapy of leukemia. When the leukemia cell line, K562, were treated by themin vitro, a sharp decrease of intracellular free Ca2+ concentration could be found. The anti-cancer mechanisms of these drugs are inhibiting the DNA or RNA syntheses and interrupting the mitoses of tumor cells. Our experiment suggested that beside the above behaviors, these anti-cancer drugs can also suppress the function of tumor cells by means of decreasing their intracellular Ca2+ levels.

Key words

Daunomycin Cyclophospamide Cytarabine Hydrochloride, Vincristine sulfale, Leukemia, Ca2+ 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    1993; 9(2):226.Google Scholar
  2. 2.
    Grynkiewtiez G. et al. Fura-2 Measurement of Cytosolic Free Ca2+ in Monolayers and Suspension of Various Types of Animal Cells. J Biol Chem 1985; 260:3440.Google Scholar
  3. 3.
    1992; 8(1):1.Google Scholar
  4. 4.
    Pesseh IN. Calcium release channel of sarcoplasmic reticulum; an important target for doxorubicin-mediated cardiotoxicity. Adv Exp Med Biol 1992; 311:409.Google Scholar
  5. 5.
    Kadam S, et al. Reveral of multidrug resistance by two novel indole derivatives. Cancer Res. 1992; Suppl. 52(17):735.Google Scholar

Copyright information

© Chinese Journal of Cancer Research 1993

Authors and Affiliations

  • Lu Chengrong 
    • 1
  • Liu Yaning 
    • 1
  • Wang Hui 
    • 1
    • 2
  1. 1.Basic LaboratoryXidiaoyutai HospitalBeijing
  2. 2.Department of HaemotologyGreatwall HospitalBeijing

Personalised recommendations