Serum sialic acid in neoplasm of head and neck
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The mean value of serum sialic acid in benign conditions was significantly higher (P<0.05) than the control group, due to tissue proliferation. SSA level in malignant group was even more higher (P<0.01) and the highest SSA level was observed in malignancy of hypopharynx, could be due to more advanced and aggressive tumour. In advanced malignancy with metastasis the SSA level was even more higher in comparison to localised malignancy, this is by tissue destruction and increased synthesis of glycoproteins by liver. Haemoglobulin and serum proteins levels gradually decreased and SSA levels increased as the cancer stage advanced. Thus estimation of S SA level is an additional biochemical tumour marker to differentiate between the benign and malignant tumours.
KeywordsSialic Acid Rickets Benign Condition Tissue Proliferation Advanced Malignancy
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