Serum sialic acid in neoplasm of head and neck
The mean value of serum sialic acid in benign conditions was significantly higher (P<0.05) than the control group, due to tissue proliferation. SSA level in malignant group was even more higher (P<0.01) and the highest SSA level was observed in malignancy of hypopharynx, could be due to more advanced and aggressive tumour. In advanced malignancy with metastasis the SSA level was even more higher in comparison to localised malignancy, this is by tissue destruction and increased synthesis of glycoproteins by liver. Haemoglobulin and serum proteins levels gradually decreased and SSA levels increased as the cancer stage advanced. Thus estimation of S SA level is an additional biochemical tumour marker to differentiate between the benign and malignant tumours.
KeywordsSialic Acid Rickets Benign Condition Tissue Proliferation Advanced Malignancy
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- 1.Gupta, A.K., Sur, B.K. and Taneja, D.K. (1973): Serum sialic acid in different bone disorders :J. Ind. Med. Assoc. 60: 87–89,Google Scholar
- 2.Lodha, S. K., Kalra, U.B., Mathur, J. S., Saxena, H., Utreja, S. R. and Sareen P. M. (1979): Serum sialic acid in cancer.Ind. J. Surg. 41 : 442–444.Google Scholar
- 3.Malti, P., Das, P. and Chaudhary, J. R. (1983) : Serum acid level under different conditions, including malignancy :Ind. J. Med. Res. (July supplement), pp. 137–140.Google Scholar
- 4.Sharma, N. C., and Sur, B. K. (1967): Serum fucose and sialic acid levels in Indian children and adults under normal and pathological conditions :Ind. J. Med. Res. 55: 380–384,Google Scholar
- 5.Singh, R. and Ramaraju, B. (1967): Serum sialic acid value in healthy Indian adults :Ind. J. Med. Res. 55: 267–269.Google Scholar
- 6.Singh, R., Sur, B. K., Agarwal, S. X. and Ramaraju, B. (1967): Serum sialic acid in malignancy :Ind. J. Med. Res. 55: 270–273.Google Scholar
- 7.Vijay, G. S., Vijay, R. K., Lodha, S. K. and Sareen, P. M. (1982): Serum sialic acid in bone tumours :Ind. J. Surg. 44: 158–160.Google Scholar
- 8.Winzler, R. J. (1935): “Methods in Biochemical Analysis”, Vol. II, (Editor : D. Glick) Interscience Publishers, New York, p. 294.Google Scholar