Canadian Anaesthetists’ Society Journal

, Volume 7, Issue 4, pp 423–428 | Cite as

Induced sympathetic stimulation during halothane anaesthesia

  • R. A. Millar
  • M. E. Morris


In an attempt to assess the sympathoadrenal responses to hypercarbia and haemorrhage during halothane anaesthesia, plasma adrenalin and noradrenalin concentrations were determined in dogs maintained in a steady state of anaesthesia by ventilation with 2 per cent halothane in oxygen. During uncomplicated halothane anaesthesia no significant increase or decrease in adrenalin or noradrenalin could be measured. Elevation of arterial pCO2 was accompanied by significant rises in plasma catecholamine levels; mean arterial blood pressure was reduced during hypercarbia. Haemorrhage induced variable increases in adrenalin, with less effect on noradrenalin. The results indicate that depression of sympathetic activity cannot be assumed to occur during surgical anesthesia with halothane.


Halothane Arterial Blood Pressure Halothane Anaesthesia Fluothane Arterial pCO2 
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Dans le but ďévaluer les réponses sympathico-surrénaliennes à ľhypercarbie et à ľhémorragie au cours de ľanesthésie à ľhalothane, nous avons recherché chez des chiens maintenus à des niveaux ďanesthésie constants, à ľaide ďune ventilation avec de ľhalothane à 2% et de ľoxygène, les concentrations ďadrénaline et de noradrénaline plasmatiques. Nous n’avons pas observé, au cours de ľanesthésie sans complication à ľhalothane, ni de diminution ni ďaugmcntation importante de ľadrénaline ou de la noradrénaline. Ľélévation du pCO2 artériel s’est accompagnée ďaugmentations importantes dans le plasma des taux de catecholamine; au cours de ľhypercarbie, la pression artérielle moyenne s’est abaissée. Ľhémorragie a entraîné des augmentations variables de ľadrénaline, mais a produit moins ďeffet sur la noradrénaline. Les résultats nous permettent de constater que, au cours de ľanesthésie chirurgicale à ľhalothane, on ne peut pas présumer ďune dépression de ľactivité sympathique.


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Copyright information

© Canadian Anesthesiologists 1960

Authors and Affiliations

  • R. A. Millar
    • 1
  • M. E. Morris
    • 1
  1. 1.Department of AnaesthesiaMontreal Neurological Institute, and McGill UniversityMontreal

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