Advertisement

Pacatal in cardio-pulmonary surgery

  • J. -P. Dechêne
Article
  • 109 Downloads

Conclusion

The potentiated anaesthesia with Pacatal in cardio-pulmonary surgery certainly presents advantages, above all in regard to cardiac protection: absence or marked reduction of ventricular fibrillation in experimental cardiac surgery in dogs, and absence of arrhythmia and cardiac arrest in thoracic pulmonary surgery in man. Moreover, the 500 different studies made on dogs clearly demonstrate that Pacatal is not a dangerous drug. Many times the effective dose of Pacatal has been injected in dogs without any toxic effect. Femoral and intra-cardiac pressures and cardiac output are very slightly changed, as are the blood constituents. Finally, in the remote premedication for anxious subjects, Pacatal is probably the ataraxic that can be prescribed with the minimum of danger and the maximum of efficiency.

Pacatal, therefore, ensures a better preoperative sedation, a smoother induction of anaesthesia, a more effective cardiac protection, a quieter postoperative period and has a marked anti-secretory effect. For all these reasons, in our opinion, Pacatal can certainly take an enviable place in the therapeutic arsenal of the surgeon and of the thoracic anaesthetist.

Keywords

CANADIAN Anaesthetist Pacatal Preoperative Anxiety Blood Constituent Phenothiazine Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Ľanesthésie potentialisée au Pacatal en chirurgie cardio-pulmonaire présente certainement des avantages, surtout en ce qui regarde la protection cardiaque: absence ou réduction marquée de la fibrillation ventriculaire en chirurgie cardiaque expérimentale chez le chien et absence ďarythmie et ďarrêt cardiaque chez ľhomme en chirurgie thoracique pulmonaire.

De plus les 500 études différentes faites chez le chien démontrent clairement que le Pacatal n’est pas un médicament dangereux; chez le chien, la dose utile de Pacatal a été plusieurs fois injectée sans effets mocifs.

Les pressions artérielles fémorales et intracardiaques, le débit cardiaque sont peu modifiés, et il en est de même de la formule sanguine. Enfin, cliniquement, en prémédication éloignée chez anxieux, le Pacatal est probablement ľataraxique qu’on peut prescrire avec le minimum de danger et le maximum ďefficacité. Voilà pourquoi, à notre avis, le Pacatal peut certainement prendre une place enviable dans ľarsenal thérapeutique du chirurgien et de ľanesthésiste thoracique.

References

  1. 1.
    Nieschulz, O., Popendiker, K., &Sock, K. Arzneim-Forsch4 232 (1954).Google Scholar
  2. 2.
    Donat, Klaus. On the Prevention of Disturbances of the Cardiac Rhythm in Operations. Der Anaesthetist4(3): 65 (1955).Google Scholar
  3. 3.
    Gaderman, E., &Donat, K. Influence Exerted on Irritability of the Heart m the Course of Anesthesia. Klin Wchnschr32 713 (Aug 15, 1954).CrossRefGoogle Scholar
  4. 4.
    Horatz, K. The Narcosis in Operations of the Bloodless Heart Tr 20th Internat Coll Surgeons, Geneva, p 518 (1955).Google Scholar
  5. 5.
    Horatz, K. Controlled Hypotension in Surgery. Proc World Cong. Anesthesiologists, p 136 (1955). Edited by Internat Anesth Res. Soc.Google Scholar
  6. 6.
    Davies, John I., Huggins, D. H. M., &Wolkenstein, C. F. Pacatal in Anesthesia A Preliminary Report. Canad Anaesth Soc. J.,3(3) 224 (1956).CrossRefGoogle Scholar
  7. 7.
    Jores, A. Clinic and Polyclinic at the University of Hamburg-EppendorfGoogle Scholar
  8. 8.
    Pedersen, S. Anesthesia and Stress. Proc. World Cong. Anesthesiologists, p. 17 (1955). Edited by Internat. Anesth. Soc.Google Scholar
  9. 9.
    Warner-Lambert International Pacatal Literature SurveyGoogle Scholar
  10. 10.
    Huguenard, P., &Laborit, H. Pratique de ľhibernothérapie en chirurgie et en en médecine. Paris, Masson (1954).Google Scholar
  11. 11.
    Dechêne, J. -P., Hudon, F., &Gravel, J. -A. Hypothermie et chirurgie intracardiaque expérimentale. Laval méd21 (3) (mars 1956).Google Scholar
  12. 12.
    Hudon, F., &Dechêne, J.-P. Contribution de ľanesthésie à la chirurgie thoracique en tuberculose. Laval méd.18(4) (avril 1953).Google Scholar

Copyright information

© Canadian Anesthesiologists 1957

Authors and Affiliations

  • J. -P. Dechêne
    • 1
  1. 1.Laval HospitalSte-Foy, Québec

Personalised recommendations