Advertisement

Canadian Anaesthetists’ Society Journal

, Volume 4, Issue 4, pp 378–383 | Cite as

Methitural sodium for the induction of paediatric anaesthesia

  • Code Smith
Article

Summary

Experience with methitural sodium in 225 children ranging from one day to sixteen years of age indicates that this agent may be safely administered to all age groups and for all procedures in which other barbiturates are not contraindicated.

The annoyances of induction are the same as those reported for adults. coughing, sneezing, hiccoughing, retching, and pain at the site of injection. The prolonged induction period was a disadvantage in some children who were apprehensive and restless.

Our experience lends clinical support to the contention that methitural has a shorter duration of action than does thiopental. This property offers some advantage to those patients who may become hypothermic during operation, either deliberately or incidentally. It is of no advantage in normothermic cases lasting longer than thirty minutes, but is of value in shorter proqedures, particularly for out-patients.

Keywords

Barbiturate Thiopental Cent Solution Fluothane Paediatric Anaesthesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    O’Herlihy, D. B., Nishimura, N., Little, D.M., &Tovell, R. M.: The Clinical Usage of Neraval. Canad. Anaesth. Soc. J.3. 326–334 (1956).CrossRefGoogle Scholar
  2. 2.
    Houde, J., Hudon, F., &Jacques, A.: Neraval (Methitural Sodium) (SCH 3132). Canad. Anaesth. Soc. J.4: 43–46 (1957).PubMedCrossRefGoogle Scholar
  3. 3.
    Fleming, S. A., &Robinson, J. G.: Neraval Sodium: A Clinical Investigation. Canad. Anaesth. Soc. J.4: 52–54 (1957).CrossRefGoogle Scholar
  4. 4.
    Boone, J. D., Muñoz, R., &Dillon, J. B.: Neraval Sodium. A New Ultra-Short-Acting Thiobarbiturate: Preliminary Clinical Investigations. Anesthiology.17. 284–287 (1956).CrossRefGoogle Scholar
  5. 5.
    Ayd, F. J., Jr.: Neraval. A New Anesthetic for Electroconvulsive Therapy. Progress Report to Schering Corporation, Bloomfield, N.J.Google Scholar
  6. 6.
    Riffin, I. M., &Block, M.: Induction of General Anesthesia with a New Ultra-Short Acting Agent, Methitural Sodium. Electrocardiographic Studies. To be published.Google Scholar
  7. 7.
    Irwin, S., Stagg, R. D., Dunbar, E., &Govier, W. M.: A New Ultra-Short Acting Intravenous Anesthetic. J Pharmacol & Exper. Therap.116. 32 (1956).Google Scholar

Copyright information

© Canadian Anesthesiologists 1957

Authors and Affiliations

  • Code Smith
    • 1
  1. 1.Department of AnaesthesiaUniversity of TorontoToronto

Personalised recommendations