Advertisement

Acta Endoscopica

, Volume 28, Issue 3, pp 213–220 | Cite as

Infection parHelicobacter pylori chez l'enfant

  • P. Bontems
  • S. Cadranel
Helicobacter Pylori
  • 33 Downloads

Résumé

La prévalence de l'infection parHelicobacter pylori est très élevéec dans les pays en voie de développement où l'infection primaire est acquise dès l'enfance. Elle peut jouer un rôle comme facteur aggravant de la malnutrition. Son incidence durant l'enfance décroît dans les pays industrialisés. Chez l'enfant, les ulcères peptiques sont rares alors que la gastrite chronique est plus répandue. Un aspect endoscopique micronodulaire typique de l'antre est fréquemment observé, de même que des follicules lymphoïdes, souvent observés chez l'enfant. Les autres caractéristiques comprennent une réponse sérologique faible, probablement due à une immaturité immunologique. La symptomatologie est changeante et dans de nombreux cas peut être silencieuse alors que chez les jeunes enfants, elle peut être présente avec des vomissements et même de la diarrhée. Le test non invasif à l'urée13C est particulièrement indiqué chez l'enfant et a été simplifié et validé en tant qu'outil diagnostique fiable. L'apparition de souches résistantes est un véritable problème surtout en Afrique. Bien que le traitement n'ait pas encore été standardisé, la trithérapie comprenant les inhibiteurs de la pompe à protons est recommandée mais des études contrôlées, encore rares dans ce groupe d'âge, sont nécessaires.

Mots-clés

enfants épidémiologie Helicobacter pylori test à l'uréase C13 serologie 

Helicobacter pylori infection in children

Summary

The prevalence ofHelicobacter pylori infection is very high in the developing world where primary infection is acquired during early infancy. It may play a role as aggravating factor of malnutrition. Its incidence during childhood is decreasing in industrialised countries. In children, peptic ulcers are rare whereas chronic gastritis is common. A typical micronodular endoscopic aspect of the antrum is frequently observed, together with lymphoid folicles. Other characteristics include a low serologic response, probably due to immunologic immaturity. Symptomatogy is versatile and, in many cases can be silent whereas in small children it may present with vomiting and perhaps diarrhoea. The non-invasive 13C-urea breath test is particularly indicated in children and has been simplified and validated as a reliable diagnostic tool. Energing resistant strains are a problem of concern, especially in Africa. Although treatment has not yet been standardised, triple therapy including proton pump inhibitors is recommended but controlled studies, rare in this age group are necessary.

Key-words

children 13C-urea breath test epidemiology Helicobacter pylori serology 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. 1.
    MARSHALL B.J., WARREN J.R. — Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.Lancet, 1984,i, 1311–1315.CrossRefGoogle Scholar
  2. 2.
    HILL R., PEARMAN J., WORTHY P., CARUSO V., GOODMAN S., BLINCOW E. —Campylobacter pyloridis in children.Lancet, 1986,i, 387.CrossRefGoogle Scholar
  3. 3.
    CADRANEL S., GOOSSENS H., DE BOECK M., MALENGREAU A., RODESCH P., BUTZLER J.P. —Campylobacter pyloridis in children.Lancet, 1986,i, 735–736.CrossRefGoogle Scholar
  4. 4.
    CZINN S.J., DAHMS B.B., JACOBS G.H., KALLEN B., ROTHSTEIN F.C. — Campylobacter-like organisms in association with symptomatic gastritis in children.J. Pediatr., 1986,109, 80–83.PubMedCrossRefGoogle Scholar
  5. 5.
    FIEDOREK S.C., MALATY H.M., EVANS D.L., PUMPHREY C.L., CASTEEL H.B., EVANS D.J., GRAHAM D.Y._ — Factors influencing the epidemiology ofHelicobacter pylori infection in children.Pediatrics, 1991,88, 578–582.PubMedGoogle Scholar
  6. 6.
    MALATY H.M., GRAHAM D.Y. — Importance of childhood socio-economic status on the current prevalence ofHelicobacter pylori infection.Apmis, 1994,102, 57–64.Google Scholar
  7. 7.
    CLEMENS J., ALBERT M.J., RAO M., HUDA S., QADRI F., VAN LOON F.P., PRADHAN B., NAFICY A., BANIK A. — Socio-demographic, hygienic and nutritional correlates ofHelicobacter pylori infection of young Bangladeshi children.Aliment. Pharmacol. Ther., 1996,10, 1015–1019.CrossRefGoogle Scholar
  8. 8.
    GURAKAN F., KOCAK N., YUCE A. —Helicobacter pylori serology in childhood.Gut, 1996,39, 18–21.CrossRefGoogle Scholar
  9. 9.
    Mc CALLION W.A., MURRAY L.J., BAILIE A.G., DALZELL A.M., O'REILLY D.P., BAMFORD K.B. —Helicobacter pylori infection in children: relation with current house-hold living conditions.Gut, 1996,39, 18–21.CrossRefGoogle Scholar
  10. 10.
    LEWINDON P.J., LAU D., CHAN A., TSE P., SULLIVAN P.B. —Helicobacter pylori in an institution of disabled children in Hong Kong.Dev. Med. Child. Neurol., 1997,39, 682–685.PubMedGoogle Scholar
  11. 11.
    GRANSTRÖM M., TINDBERG Y., BLENNOW M. — Seroepidemiology ofHelicobacter pylori infection in a cohort of children monitored from 6 months to 11 years of age.J. Clin. Microbiol., 1997,35, 468–470.PubMedGoogle Scholar
  12. 12.
    SIPPONEN P. —Helicobacter pylori gastritis-epidemiology.J. Gastroenterol., 1997,32, 273–277.PubMedCrossRefGoogle Scholar
  13. 13.
    GOODMAN K.J., CORREA P., TENGANA AUX H.J., DELANY J.P., COLLAZOS T. — Nutritional factors andHelicobacter pylori infection in Colombian children.J. Pediatr. Gastroenterol. Nutr., 1997,25, 507–515.PubMedCrossRefGoogle Scholar
  14. 14.
    KEHRT R., BECKER M., BROSICKE H., KRUGER N., HELGE H. — Prevalence ofHelicobacter pylori infection in Nicaraguan children with persistent diarrhea, diagnosed by the 13C-urea breath test.J. Pediatr. Gastroenterol. Nutr., 1997,25, 84–88.PubMedCrossRefGoogle Scholar
  15. 15.
    OLIVEIRA A.M., QUEIROZ D.M., ROCHA G.A., MENDES E.N. — Seroprevalence ofHelicobacter pylori infection in children of low socioeconomic level in Belo Horizonte, Brazil.J. Infect. Dis., 1994,170, 1634–1636.Google Scholar
  16. 16.
    PELSER H.H., HOUSEHAM K.C., JOUBERT G., VAN DER LINDE G., KRAAIJ P., MEINARDI M., McLEOD A., ANTHONY M. — Prevalence ofHelicobacter pylori antibodies in children in Bloemfontein, South Africa.J. Pediatr. Gastroenterol. Nutr., 1997,24, 135–139.PubMedCrossRefGoogle Scholar
  17. 17.
    SULLIVAN P.B., THOMAS J.E., WIGHT D.G.D., NEALE G., EASTHAM E.J., CORRAH T., LLOYD-EVANS N., GREENWOOD B.M. —Helicobacter pylori in Gambian children with chronic diarrhoea and malnutrition.Arch. Dis. Child., 1990,65, 189–191.PubMedCrossRefGoogle Scholar
  18. 18.
    LEE A. — The nature ofHelicobacter pylori.Scand. J. Gastroenterol., 1996,31, 5–8.CrossRefGoogle Scholar
  19. 19.
    EL-OMAR E.M., PENMAN I.D., ARDILL J.E., CHITTA-JALLU R.S., HOWIE C., McCOLL K.E. —Helicobacter pylori infection and abnormalities of acid secretion in patient with duodenal ulcer disease.Gastroenterology, 1995,109, 681–691.PubMedCrossRefGoogle Scholar
  20. 20.
    McCOLL K., EL-OMAR E. —Helicobacter pylori and disturbance of gastric function associated with duodenal ulcer disease and gastric cancer.Scand. J. Gastroenterol., 1996,215 (suppl), 32–37.CrossRefGoogle Scholar
  21. 21.
    WEISS S.J. — Tissue destruction by neutrophils.N. Engl. J. Med., 1989,320, 365–376.PubMedGoogle Scholar
  22. 22.
    NEGRINI R., SAVIO A., POIESI C., APPELMELK B., BUFFOLI F., PATERLINI A., CESARI P., GRAFFEO M., VAIRA D., FRANZIN G. — Antigenic mimicry betweenHelicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis.Gastroenterology, 1996,111, 655–665.PubMedCrossRefGoogle Scholar
  23. 23.
    APPELMELK B.J., SIMOONS-SMIT I., NEGRINI R., MORAN A.P., ASPINALL G.O., FORTE J.G. DE VRIES T., QUAN H., VERBOOM T., MAASKANT J.J., GHIARA P., KUIPERS E.J., BLOEMENA E., TADEMA T.M., TOWNSEND R.R., TYAGARAJAN K., CROTHERS J.M., Jr, MONTEIRO M.A., SAVIO A., DE GRAAF J. — Potential role of molecular mimicry betweenHelicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity.Infect. Immun., 1996,64, 2031–2040.PubMedGoogle Scholar
  24. 24.
    BUJANOVER, Y., KONIKOFF F., BARATZ M. — Nodular gastritis andHelicobacter pylori.J. Pediatr. Gastroenterol. Nutr., 1990,11, 41–44.PubMedGoogle Scholar
  25. 25.
    LAMIREAU T., RIGOT A., MEGRAUD F., DE MASCAREL A. — Gastrite àHelicobacter pylori chez l'enfant.Arch. Pédiatr., 1995,2, 310–316.PubMedCrossRefGoogle Scholar
  26. 26.
    HELDENBERG D., WAGNER Y., HELDENBERG E., KEREN S., AUSLAENDER L., KAUFSHTEIN M., TENEBAUM G. — The role ofHelicobacter pylori in children with recurrent abdominal.Am. J. Gastroenterol., 1995,90, 906–909.PubMedGoogle Scholar
  27. 27.
    BLECKER U., HAUSER B., LANCIERS S., KEYMOLEN K., VANDENPLAS Y. — Symptomatology ofHelicobacter pylori infection in children.Acta Paediatr., 1996,85, 1156–1158.PubMedGoogle Scholar
  28. 28.
    OZTURK H., SENOCAK M.E., UZUNALIMOGLU B., HASCELIK G., BUYUKPAMUKCU N., HICSONMEZ A. —Helicobacter pylori infection in symptomatic and asymptomatic children: a prospective clinical study.Eur. J. Pediatr. Surg., 1996,6, 265–269.PubMedCrossRefGoogle Scholar
  29. 29.
    Mac ARTHUR C., SAUNDERS N., FELDMAN W. —Helicobacter pylori, gastro-duodenal disease and recurrent abdominal pain in children.JAMA, 1995,273, 729–734.CrossRefGoogle Scholar
  30. 30.
    GORMALLY S.M., PRAKASH N., DURNIN M.T., DALY L.E., CLYNE M., KIERCE B.M., DRUMM B. — Association of symptoms withHelicobacter pylori infection in children.J. Pediatr., 1995,126, 849–850.Google Scholar
  31. 31.
    DELTENRE M., GLUPCZINSKI Y., DEPREZ C., NYST J.F., BURETTE A. — The reliability of urease test, histology and culture in the diagnosis ofCampylobacter pylori infection.Scand. J. Gastroenterol., 1989,160 (suppl), 19–24.CrossRefGoogle Scholar
  32. 32.
    GLUPCZYNSKI Y., LABBE M., HANSEN W., CROKAERT F., YOURASSOWSKY E. — Evaluation of the E test for quantitative antimicrobial susceptibility testing ofHelicobacter pylori.J. Clin. Microbiol., 1991,29, 2072–2075.PubMedGoogle Scholar
  33. 33.
    CORVAGLIA L., BONTEMS P., KEPPENS E., VANDEN-BORRE C. DE PREZ C., CADRANEL S. —Helicobacter pylori infection in children: comparison of results with serology and13C-urea breath test.Gut, 1997, suppl. 1, vol. 41, A68.Google Scholar
  34. 34.
    CADRANEL S., CORVAGLIA L., BONTEMS P., DE OLIVEIRA ANDRADE D., KEPPENS F. — Detection ofHelicobacter pylori infection by a non invasive method: standardisation of the 13C-urea breath test in children.J. Pediatr. Gastroenterol. Nutr., 1996,22, 431 (abstract).Google Scholar
  35. 35.
    CADRANEL S. — Etudes de l'efficacité des médicaments de l'infection àHelicobacter pylori chez l'enfant. In PONS G., DUPONT C. (eds). Les médicaments du reflux gastro-œsophagien et de l'infection àHelicobacter pylori chez l'enfant.Springer-Verlag (Paris) 1996, 179–191.Google Scholar
  36. 36.
    GLUPCZINSKI Y. — Results of multicentre European survey in 1991 of metronidazole resistance inHelicobacter pylori.Eur. J. Clin. Microbiol. Infect. Dis., 1992,11, 777–781.CrossRefGoogle Scholar
  37. 37.
    DE OLIVEIRA AANDRADE D., BONTEMS P., CORVAGLIA L., SCAILLON M., CADRANEL S. — Increasing resistance ofHelicobacter pylori to antibiotics: usefulness of culture and antibiograms.J. Pediatr. Gastroenterol. Nutr., 1996,22, 432 (abstract).Google Scholar
  38. 38.
    BLECKER U., HAUSER B., LANCIERS S., PEETERS S., SUYS B., FANNES F., VANDENPLAS Y. — The prevalence ofHelicobacter pylori positive serology in asymptomatic children.J. Pediatr. Gastroenterol. Nutr., 1993,16, 252–256.PubMedCrossRefGoogle Scholar
  39. 39.
    KONTIAINEN S., SEPPALA I., MIETTINEN A., KOSUNEN T.U., VERKASALO M., MAENPAA J. — Antibodies against some bacterial antigens in children.Rinsho Byori, 1994,42, 1188–1193.Google Scholar
  40. 40.
    PATEL P., MENDALL M.A., KHULUSI S, NORTHFIELD T.C., STRACHAN D.P. —Helicobacter pylori infection in childhood: risk factors and effect on growth.Acta Paadiatr., 1994,83, 1137–1142.Google Scholar
  41. 41.
    RODRIGO SAEZ L., RIESTRA MENENDEZ S., FERNANDEZ RODRIGUEZ E., FERNANDEZ VELAZQUEZ M.R., GARCIA ALONSO S., LAURET BRANA M.E. — Epidemiological study of the prevalence ofHelicobacter pylori infection in the general population in Asturias, Spain.Rev. Esp. Enferm. Dig., 1997,87, 511–522.Google Scholar

Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  1. 1.Department of Gastroenterology and HepatologyQueen Fabiola Children's HospitalBrusselsBelgium

Personalised recommendations