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Canadian Anaesthetists’ Society Journal

, Volume 5, Issue 2, pp 161–169 | Cite as

The combined action of pentobarbital and meperidine, and of procaine and meperidine, in guinea pigs

  • Madelaine O. Maykut
Article

Summary

Meperidine increases the sleeping time induced by pentobarbital in guinea pigs.

The effect of pentobarbital on the toxicity of meperidine was antagonistic, whereas the effect of meperidine on the toxicity of pentobarbital was nearly additive.

The results of these experiments show that pentobarbital will protect experimental animals against the convulsive effects of meperidine and that the depressant action of pentobarbital is augmented by the presence of meperidine It has been pointed out that when meperidine and procaine are combined there is a potentiation of convulsive effects, but their combined lethal effects, while greater than that of either one alone, are not additive.

Keywords

Pentobarbital Barbiturate Meperidine CANADIAN Anaesthetist Procaine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

RÉsumÉ

Des résultats expérimentaux ont laissé croire que la meperidine (Demerol®) avait un certain pouvoir comme anesthésique local et qu’elle pourrait diminuer également la quantité de barbiturique requise pour produire une narcose satisfaisante Il nous a donc paru intéressant de vérifier si la rneperidine n’augmenterait pas ľaction de la procaine (un anesthésique local) et de vérifier également si ľeffet associé de la meperidine et du pentobarbital (un barbiturique) ne présenterait pas des tendances à la fois antagoniste et synergique comme on ľavait découvert au préalable pour la procame et le pentobarbital.

Chez les cobayes, ľexpérience a démontré que la meperidine augmente la durée du sommeil provoqué par le pentobarbital. Nous avons déterminé les doses toxiques (LD50) de ces médicaments employés seuls ou associés. Sur la toxicité de la meperidine, la pentobarbital s’est révélé un antagoniste et, sur la toxicité du pentobarbital, la meperidine a semblé avoir un effet presqu ’additionnel. Les résultats de ľexpérience font croire que le pentobarbital peut protéger les animaux contre les effets convulsivants de la meperidine et que cette même meperidine augmente ľaction déprimante du pentobarbital.

Si ľon associe la meperidine et la procaine, il se produit une potentialisation de leurs effets convulsivants mais leurs doses léthales associées ne s’additionnent pas bien qu’elles soient plus grandes que ľune ou ľautre seule. Les mécanismes en jeu à ľoccasion de convulsions peuvent être différents puisque les courbes obtenues pour les doses convulsivantes de ces médicaments 50 (CD50) sont différentes. Ainsi, les courbes obtenues pour le CD50 et le LD50 de ľun ou ľautre des médicaments, sont différentes, ce qui peut laisser croire que le mécanisme qui entre en jeu à ľoccasion de convulsions est différent de celui qui cause la mort.

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Copyright information

© Canadian Anesthesiologists 1958

Authors and Affiliations

  • Madelaine O. Maykut
    • 1
  1. 1.Department of PharmacologyUniversity of TorontoToronto

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