Summary and conclusion
-
1.
Calcium carbonate and aluminum hydroxide preparation, magnesium hydroxide and sodium lauryl sulfate caused decreased peptic activity simultaneously with a rise in the pH.
-
2.
Calcium carbonate, the aluminum hydroxide preparation and magnesium hydroxide caused more marked peptic inhibition than sodium lauryl sulfate.
-
3.
In our studies we were unable to confirm the reported observations that sodium lauryl sulfate inhibits peptic activity in the presence of an unaltered pH.
-
4.
Clinical use of sodium lauryl sulfate on a small number of patients on the usual dietary peptic ulcer management failed to reveal any superiority of this medication over some of the other medications used.
Similar content being viewed by others
References
Mann, F. C. and Williamson, C. S. Experimental Production of Peptic Ulcer. Ann. Surg., 77:409, 1923.
Matthews, W. B. and Dragstedt, L. R. Etiology of Gastric and Duodenal Ulcer; Experimental Studies. Surg. Gynec, & Obst, 55:265, 1932.
Palmer, Walter L. Peptic Ulcer and Gastric Secretion. Arch. Surg., 44:452, 1942.
Schiffrin, M. J. and Warren, A. A. Some Factors Concerned in the Production of Experimental Ulceration of the G-I Tract in Cats. Am. J. Digest. Dis., 9:205, 1942.
Schiffrin, M. J. and Ivy, A. C. Physiology of Gastric Secretion, Particularly as Related to the Ulcer Problem. Arch. Surg., 44:399, 1942.
Buchner, F. Die Pathogenese der Peptischen Veranderungen. Jena, Gustav Fischer, 1931.
Varco, R. L., Code, C. F., Walpole, S. H. and Wangensteen, O. H. Duodenal Ulcer Formation in the Dog by Intramuscular Injections of a Histamine Beeswax Mixture. Am. J. Physiol., 133:475, 1941.
Bucher, G. R. and Ivy, A. C. The Inherent Inadequacies of the Double Histamine Test for Studies on Pepsin Secretion. Am. J. Physiol., 132:654, 1941.
Shoch, D. and Fogelson, S. J., Quart. Bull. Northwestern Univ. Med. School, 1942, 16:2.
Shoch, D. and Fogelson, S. J. Studies on Peptic Inhibition. Proc. Soc. Exper. Biol. & Med., 50:304, 1942.
Anson, M. L. and Mirsky, A. E. Estimation of Pepsin with Hemoglobin. J. Gen. Physiol., 16:59, 1932.
Steigmann, F. and Marks, A. R. Clinical Studies on a New Pepsin Inhibitor. Proc. Soc. Exper. Biol. & Med., 54:25,1943.
Komarov, S. A. and Komarov, O. The Precipitability of Pepsin by Colloidal Aluminum Hydroxide. Am. J. Digest. Dis., 7:166, 1940.
Schiffrin, M. J. and Komarov, S. A. The Inactivation of Pepsin by Compounds of Aluminum and Magnesium. Am. J. Digest. Dis., 8:215, 1941.
Warren, I. A., Front, J. and Kirsner, J. B. The Effect of Antacid Therapy on the Peptic Activity of Gastric Juice in Man. Gastroenterology, 1:102, 1943.
Kirsner, J. B. and Wolff, R. A. Effect of Sodium Alkyl Sulfate on Peptic Activity of Gastric Contents in Man and in Vitro. Proc. Soc. Exper. Biol. & Med., 54:11, 1943.
Author information
Authors and Affiliations
Additional information
Aided by a grant from the Nutrition Research Laboratories, Chicago.
Rights and permissions
About this article
Cite this article
Steigmann, F., Marks, A.R. Inhibition of peptic activity in the treatment of peptic ulcer. Jour. D. D. 11, 173–178 (1944). https://doi.org/10.1007/BF03020248
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03020248