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Canadian Journal of Anesthesia

, Volume 51, Issue 9, pp 918–922 | Cite as

0.2% ropivacaine and levobupivacaine provide equally effective epidural labour analgesia

  • Mia Supandji
  • Alex T. H. Sia
  • Cecilia E. Ocampo
Obstetrical and Pediatric Anesthesia

Abstract

Purpose

To compare the duration of epidural analgesia induced by levobupivacaine and ropivacaine at clinically relevant doses.

Methods

Forty healthy nulliparous parturients with cervical dilatation of 3 to 5 cm and at least one contraction every two or three minutes were recruited. Patients were randomly assigned to receive either 10 mL of 0.2% ropivacaine or 10 mL of 0.2% levobupivacaine. Preblock visual analogue scale (VAS) score (0–100) and VAS score after five, ten, 15, 20, 25 and 30 min from time0 and VAS at time of request for additional analgesia (timeend) were recorded. During the first 30 min after the completion of epidural injection, the systolic blood pressure, highest sensory level to cold and the maximum degree of motor block based on a 0 to 3 modified Bromage scale were collected every five minutes. The duration of analgesia was defined as the time from time0 to timeend.

Results

There was no difference in the duration of analgesia between the two groups; similarly, there was no significant difference found in the area under the curve (AUC) time15-time0 and AUC time30-time0 for VAS. The highest sensory block to cold and the degree of motor block were also indistinguishable between the two groups. No difference in the serial systolic blood pressures was found.

Conclusion

Ten millilitres of either 0.2% ropivacaine or levobupivacaine can be used to induce epidural labour analgesia effectively without a difference in the duration of pain relief.

Keywords

Visual Analogue Scale Bupivacaine Visual Analogue Scale Score Ropivacaine Epidural Analgesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

La ropivacaïne et la lévobupivacaïne à 0,2 % par voie épidurale ont un effet analgésique similaire pendant le travail

Résumé

Objectif

Comparer la durée de l’analgésie péridurale induite par la lévobupivacaïne et la ropivacaïne administrées selon les doses cliniques appropriées.

Méthode

Quarante parturientes nullipares en bonne santé, chez qui la dilatation cervicale était de 3 à 5 cm et les contractions aux 2 ou 3 minutes, ont participé à l’étude. Elles ont été réparties au hasard pour recevoir soit 10 mL de ropivacaïne à 0,2 %, soit 10 mL de lévobupivacaïne à 0,2 %. Les scores préanalgésiques à l’échelle visuelle analogique (EVA) de 0–100, puis les scores à 5, 10, 15, 20, 25 et 30 min du temps0 et au moment de la demande d’analgésiques supplémentaires (tempsfinal) ont été enregistrés. Pendant les 30 premières minutes suivant l’injection péridurale, la tension artérielle systolique, le plus haut niveau sensitif au froid et le degré maximal de bloc moteur, à l’échelle de Bromage modifiée de 0 à 3, ont été notés toutes les cinq minutes. La durée de l’analgésie a été déterminée comme le temps écoulé entre le temps0 et le tempsfinal

Résultats

La durée de l’analgésie a été similaire dans les deux groupes; de même, il n’y a pas eu de différence significative pour l’aire sous la courbe (ASC) du temps15-temps0 et de l’ASC du temps30-temps0. Le plus haut bloc sensitif au froid et le degré de bloc moteur, de même que la série de tensions artérielles systoliques étaient similaires dans les deux groupes.

Conclusion

Dix millilitres de ropivacaïne ou de lévobupivacaïne à 2 % peuvent induire efficacement l’analgésie péridurale du travail et produire la même durée d’analgésie.

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Copyright information

© Canadian Anesthesiologists 2004

Authors and Affiliations

  • Mia Supandji
    • 1
  • Alex T. H. Sia
    • 1
  • Cecilia E. Ocampo
    • 1
  1. 1.Department of Anesthesia O & GKK Women and Children HospitalSingapore

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