Intrathecal lidocaine and sufentanil shorten postoperative recovery after outpatient rectal surgery

  • Beverly Waxler
  • Shirley A. Mondragon
  • Sonal N. Patel
  • Kochuthresia Nedumgottil
Regional Anesthesia and Pain



A short recovery time for same day surgery is important to the patient and the hospital. A prospective, randomized, doubleblinded study in the postanesthetic care unit was designed to compare the recovery time from spinal anesthesia with low-dose intrathecal (IT) lidocaine and sufentanil to that with IT lidocaine alone. The incidence of adverse effects was also assessed.


Forty-nine patients (ASA I-III, age 20–69 yr) underwent spinal anesthesia for rectal surgery. The patients were randomized into two groups. One group (n = 28) received low-dose IT lidocaine (15 mg) and sufentanil (10 μg) and the other group (n = 21) received IT lidocaine (SO mg). The time to ambulation, the incidence of pruritus, and other variables were recorded. Statistical difference was assumed if P < 0.05.


Our results show a significantly shorter ambulation time (120 ± 26 min) after IT low-dose lidocaine (15 mg) and 10 μg sufentanil vs 50 mg IT lidocaine (162 ± 32 min, P < 0.0001). Patients who received IT lidocaine and sufentanil recovered faster. Fifty percent of the patients who received IT sufentanil suffered from pruritus.


IT lidocaine (15 mg) and sufentanil resulted in a shorter time to ambulation compared to IT lidocaine (50 mg) alone and provided excellent anesthesia despite its disadvantage of pruritus.


Lidocaine Spinal Anesthesia Ketorolac Sufentanil Nalbuphine 
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L’administration intrathécale de lidocaïne et de sufentanil diminue le temps de récupération après une opération du rectum en chirurgie ambulatoire



Une récupération rapide en chirurgie ambuiatoire est importante pour ie patient et pour i’hôpital. Une étude prospective, randomisée et à doubie insu a été réaiisée en sale de réveil pour comparer le temps de récupération d’une rachianesthésie avec de faibles doses intrathécaies (IT) de lidocaïne et de sufentanil ou de lidocaïne IT seule. Lincidence d’effets indésirables a aussi été évaluée.


Quaranteneuf patients (ASA I–III, de 20 à 69 ans) ont subi une opération du rectum sous rachianesthésie. Les patients ont été randomises en deux groupes. Dans un groupe (n = 28), ils ont reçu de faibles doses de lidocaïne (15 mg) et de sufentanil (10 μg) IT et dans l’autre (n = 21), ils ont reçu de la lidocaïne (50 mg) IT Le temps requis avant de pouvoir marcher, l’incidence de prurit et d’autres variables ont été enregistrés. Une différence statistique était considérée si P < 0,05.


Nos résultats montrent un temps significativement plus court avant l’ambulation (120 ± 26 min) suivant de faibles doses de lidocaïne (15 mg) et de 10)μg de sufentanil IT vs 50 mg de lidocaïne IT (162 ± 32 min, P < 0,0001). Les patients qui ont reçu la lidocaïne et le sufentanil IT se sont remis plus rapidement. Cinquante pour cent des patients qui ont eu du sufentanil IT ont souffert de prurit.


La lidocaïne (15 mg) et le sufentanil IT, comparés à la lidocaïne seule (50 mg), permettent une récupération plus rapide de la marche et fournissent une excellente anesthésie malgré l’inconvénient du prurit.


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Copyright information

© Canadian Anesthesiologists 2004

Authors and Affiliations

  • Beverly Waxler
    • 1
  • Shirley A. Mondragon
    • 1
  • Sonal N. Patel
    • 1
  • Kochuthresia Nedumgottil
    • 1
  1. 1.Department of Anesthesiology and Pain ManagementJohn H. Stroger Jr. Hospital of Cook CountyChicagoUSA

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