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Canadian Journal of Anesthesia

, Volume 55, Issue 5, pp 311–312 | Cite as

Methylene blue is a potent monoamine oxidase inhibitor

  • P. Ken Gillman
  • Bradley K. W. Ng
  • Andrew J. D. Cameron
  • Rhea W. Y. Liang
Correspondence

Keywords

Methylene Blue Selective Serotonin Reuptake Inhibitor Hypertrophic Cardiomyopathy Laryngeal Mask Airway Neuroleptic Malignant Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Ramsay RR, Dunford C, Gillman PK. Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Br J Pharmacol 2007; 152: 946–51.PubMedCrossRefGoogle Scholar
  2. 2.
    Gillman PK. Methylene blue implicated in potentially fatal serotonin toxicity. Anaesthesia 2006; 61: 1013–4.PubMedCrossRefGoogle Scholar
  3. 3.
    Whyte IM. Serotonin toxicity (syndrome).In: Dart RC (Ed.). Medical Toxicology, 3rd ed. Baltimore: Lippincott Williams & Wilkins; 2004: 103–6.Google Scholar
  4. 4.
    Isbister GK, Bowe SJ, Dawson A, Whyte IM. Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose. J Toxicol Clin Toxicol 2004; 42:277–85.PubMedCrossRefGoogle Scholar
  5. 5.
    Gillman PK. A review of serotonin toxicity data: implications for the mechanisms of antidepressant drug action. Biol Psychiatry 2006; 59: 1046–51.PubMedCrossRefGoogle Scholar

References

  1. 1a.
    Ramsay RR, Dunford C, Gillman PK. Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Br J Pharmacol 2007; 152: 946–51.PubMedCrossRefGoogle Scholar
  2. 2.
    Gillman PK. Methylene blue implicated in potentially fatal serotonin toxicity. Anaesthesia 2006; 61: 1013–4.PubMedCrossRefGoogle Scholar
  3. 3.
    Patel AS, Singh-Ranger D, Lowery KA, Crinnion JN. Adverse neurologic effect of methylene blue used during parathyroidectomy (Letter). Head Neck 2006; 28:567–8.PubMedCrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 2008

Authors and Affiliations

  • P. Ken Gillman
    • 1
  • Bradley K. W. Ng
    • 2
  • Andrew J. D. Cameron
    • 2
  • Rhea W. Y. Liang
    • 2
  1. 1.MackayAustralia
  2. 2.Middlemore HospitalAucklandNew Zealand

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