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Analyses of thermal stress and fracture during cryopreservation of blood vessel

  • Hua Zezhao
  • Xu Hongyan
  • Zhou Guoyan
  • Liu Jinfen
  • Huang Huimin
  • Ding Wenxiang
Article
  • 68 Downloads

Abstract

The occurrence of fractures in the vessel wall has been a major problem for human blood vessel cryopreservation. The large volumetric expansion of water during crystallization produces great inner stresses. To solve these complicated heat transfer and thermal stress problems, a model and an analytic method are presented in this paper, with which transient temperature field, the transient stress field inside the blood vessels during freezing can be calculated and analyzed, and the probable cracks or fractures can be predicted. The analytic results of sheep thoracic artery are consistent with the experimental observations of fractures.

Keywords

blood vessel thermal stress fracture cryopreservation 

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Copyright information

© Science in China Press 2001

Authors and Affiliations

  • Hua Zezhao
    • 1
  • Xu Hongyan
    • 1
  • Zhou Guoyan
    • 1
  • Liu Jinfen
    • 2
  • Huang Huimin
    • 2
  • Ding Wenxiang
    • 2
  1. 1.Institute of Cryobiology and Food ScienceShanghai University of Science and TechnologyShanghaiChina
  2. 2.Shanghai Second Medical UniversityShanghaiChina

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