Analyses of thermal stress and fracture during cryopreservation of blood vessel
- 67 Downloads
The occurrence of fractures in the vessel wall has been a major problem for human blood vessel cryopreservation. The large volumetric expansion of water during crystallization produces great inner stresses. To solve these complicated heat transfer and thermal stress problems, a model and an analytic method are presented in this paper, with which transient temperature field, the transient stress field inside the blood vessels during freezing can be calculated and analyzed, and the probable cracks or fractures can be predicted. The analytic results of sheep thoracic artery are consistent with the experimental observations of fractures.
Keywordsblood vessel thermal stress fracture cryopreservation
Unable to display preview. Download preview PDF.
- 1.Hua, T. C., Cryobiomedical Techniques (in Chinese), Beijing; Science Press, 1994, 20–45; 149–152.Google Scholar
- 2.Bateson, E. A. J., Pegg, D. E., Cryopreservation of arteries, Cryo-Letters, 1994, 15: 15.Google Scholar
- 3.Zhao, M. J., Studies of blood vessel cryopreservation and its injury effects, Doctorial Dissertation, Xing-Hua Hospital affiliated to Shanghai Second Medical University, 1995.Google Scholar
- 5.Xu, H. Y., Hua, T. C., Experimental studies of the fractures of cryopreserved blood vessels, Journal of Cryogenics (in Chinese), 2000, (1): 22.Google Scholar
- 6.Shi, X., Datta, A. K., Mechanical property changes during freezing of a biomaterial, Transaction of the ASAE, 1998, 41(5): 1407.Google Scholar
- 10.Shi, X., Datta, A. K., Thermal stresses from large volumetric expansion during freezing of biomaterials, Transaction of the ASME, 1999, 120: 720.Google Scholar
- 11.Timoshenko, S., Goodier, J. N., Theory of Elastiety, 3rd ed, New York: McGraw-Hill Book Company, 1970, 443–452.Google Scholar