Chinese Journal of Cancer Research

, Volume 7, Issue 2, pp 121–126 | Cite as

First step view of the efficacy of anti-neoplastic agents

  • Yu Da 
  • Wu Jinmin 
Clinical Observations


A human K562 leukaemia cell line and acute adult leukaemia patient samples have been used to test the efficacy of antineoplastic agents with MTT assay. All 18 drugs were invoved. According to the purpose of experiment these drugs were applied at different opportunities or combinations. The drug efficacy has been observed and summarized as four different conditions: 1. The change of the time (Δ T) closely related with drug effacacy, during the duration the change of drug concentration (Δ C) at certain extent has almost no influence; 2. The Δ C closely related with the efficacy, the Δ T has no influence; 3. The Δ C and Δ T effect the results together; and 4. The Δ C and A T effect not the result. And then draw a conclution that the process of drug effacacy has a multiple function with flat district.

Key words

Antineoplastic agents Pharmacodynamics Acute leukaemia Drug effective test 


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Copyright information

© Chinese Journal of Cancer Research 1995

Authors and Affiliations

  • Yu Da 
    • 1
  • Wu Jinmin 
    • 1
  1. 1.Cancer InstituteZhejiang Medical UniversityHangzhou

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