Canadian Anaesthetists’ Society Journal

, Volume 6, Issue 1, pp 13–23 | Cite as

Fluothane and hypotension in cats

  • Anita C. Beaton


The hypotensive action of Fluothane in cats receiving autonomic blocking agents was compared with the response in unblocked cats. No effect on reflex mechanisms, the vasomotor centre, sympathetic ganglia, or nerve endings appears to play any part in the production of hypotension in the cat. Cardiac output in the intact animal receiving Fluothane was measured. From a consideration of both groups of experiments it would seem likely that Fluothane exerts its hypotensive effect by means of action on the heart and the arterioles. Coincident depression of respiration occurs.


Total Peripheral Resistance Sympathetic Ganglion Blocking Drug Fluothane Ganglion Blocker 
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Nous avons comparé ľaction hypotensive du Fluothane chez des chats qui avaient re·u des agents inhibiteurs du système nerveux autonome et chez des chats qui n’avaient rien re·u. Au cours de ľhypotension observée chez le chat, il ne semble pas exister ďaction sur les mécanismes réflexes, ni sur le centre vasomoteur, ni sur les ganglions sympathiques, ni sur les terminaisons nerveuses. Nous avons mesuré le débit cardiaque sur ľanimal intact soumis à une anesthésie au Fluothane. Si ľon fait un parallèle entre les deux groupes ďexpériences, ľaction hypotensive du Fluothane découlerait, selon toute vraisemblance, de son action sur le cœur et Sur les artérioles. Nous avons observé une dépression respiratoire concomittante.


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© Canadian Anesthesiologists 1959

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  • Anita C. Beaton

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