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Canadian Anaesthetists’ Society Journal

, Volume 7, Issue 1, pp 16–20 | Cite as

The effect of lysergic acid diethylamide (delysid, LSD-25) on thiopentl recovery

  • Allen B. Dobkin
  • John L. Pearson
  • James S. Barr
Article

Summary and Conclusions

Two groups of 55 consecutive feniale patients were observed closely to, determine the recovery time from thiopental-nitrpus oxide anaesthesia after, a short standard operative procedure. Uterine dilatation and curettage was the operation chosen because it produces very little surgical trauma and requires only a relatively light level of anaesthesia. The first group of patients served as a.control. In the second group, each patient received 25 μg. of LSD-25 immediately after the end of anaesthesia.

There was no significant difference in the time required for awakening in the two groups as measured by four end points: response to verbal command (open your eyes), sluggish verbal response (what is your name), alert verbal response (where do you live), and Bender face-hand test: (identify simultaneous touch stimulus to face and contralateral arm). There were also no distinguishing cardiovascular or overt psychic changes observed in any of the patients who received LSD-25. It was suggested, however, that one may be justified in testing the effectiveness of a much larger dose of LSD-25 when a very large overdose of a barbiturate has been injected or taken orally with suicidal intent.

Keywords

Barbiturate Thiopental Suicidal Intent Verbal Command Lysergic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Nous avons observé de près deux groupes de 55 malades consécutives pour préciser le moment du réveil à la suite ďune anesthésie au thiopenthal et protoxide ďazote apirès une courte opération opdinaire. Nous avons choisi comme opération: dilatation et curettage parce que cette opération n’occasionne qu’un très getit traumatisme et ne requiert qu’un niveau ďantesthésie plutôt superficiel.

Le premier groupe de malades nous sert de témoins. Chacune des malades du deuxième groupe a reçu 25 mg. de LSD-25 immédiatement à la fin de ľanesthésie.

Entre les deux groupes, nous n#x2019;avons pas observé de différence notable dans la durée du sommeil, évaluée de quatre façons: une réponse à un ordre verbal (ouvrez vos yeux), une réponse verbale marmottée (quel est votre nom), une réponse verbale attentive (quelle est votre adresste), le test Bender (identification simultanée des stimuli du toucher à la face et au bras opposé ) Nous n’avons pas observé non plus de changements cardiovasculaires ou ďéveil psychique chez aucune des malades qui avaient reçu LSD-25.

A la lumière de ces tests, nous concluons que LSD-25 est dépourvu ďactivité analeptique. Nous concédons, toutefois, que si un grand surdosage de barbituriques a été donné en injection ou a été absorbé par la bouche en tentative de suicide, on puisse tenter de ľemployer,

References

  1. 1.
    Stoll, A., &Hofmann, A. Partialsynthese von Aijkaloiden vom Typus des Ergobasins. Helv. chim. Acta.26: 944 (1943).CrossRefGoogle Scholar
  2. 2.
    Stoll, A. Lysergsaure-diathylamid, ein Phantastikum aus der Mutterkomgruppje. Schweiz f. Arch. Neurol. u.Psychiat.60: 279 (1947).Google Scholar
  3. 3.
    Cerletti, A., &Rothlin, E. Role of 5-hydroxVtryptamine in Mental Diseases and Its Antagonism to Lysergic Acid Derivatives. Natine.176: 785 (1955).CrossRefGoogle Scholar
  4. 4.
    Rinkel, M.;Hyde, R. W.;Solomon, H. C.; &Hoagland, H. Experimental Psychiatry: II, Clinical and Physio-Chemical Observations in Experimental Psychosis. Am. J. Psychiat.111: 881 (1955),PubMedGoogle Scholar
  5. 5.
    Berlin, L.;Guthrie, T.;Weider, A.;Gooell, H.; &Wolff, H. G. Studies in Human Cerebral Function: Effects of Mescaline and Lysergic Acid on Cerebral. Processes Pertinent to Creative Activity. J. Nerv. & Ment. Dis.122: 487 (1955).CrossRefGoogle Scholar
  6. 6.
    Forrer, G. R., &Goldner, R. D. Experimental Physiological Studies with Lysergic Acid Diethylamide (LSD-25). Arch. Neurol. & Psychiat.65: 581 (1951).Google Scholar
  7. 7.
    Rothlin, E.;Cerletti, A.;Konzett, H.;Schalch, W. R.; &Taeschler, M. Zentrale vegetative LSD-Effekte.Experientia 12:154 (1956).Google Scholar
  8. 8.
    Bradley, P. B. Effect of Some Drugs on Electrical Activity of Brain in Cat. Electroencephalog. & Clin. Neurophysiol.5: 471 (1953).Google Scholar
  9. 9.
    Brodée, B. B., &Shore, P. A. Concept for Role of Serotonin and Norepinephrine as Chemical Mediators in Brain. Ann. New York Acad. Sc.66: 631 (1957).CrossRefGoogle Scholar
  10. 10.
    Apter, J. T. Analeptic Action of Lysergic Acid Diethylamide (LSD-25) against Pentobarbital. A.M.A. Arch. Neurol, & Psychiat.79: 7111 (1958).Google Scholar
  11. 11.
    Dobkin, A. B., &Harland, J. H. Drugs which Stimulate Affective Behaviour: I, Action of LSD-25 against Thiopental in Dogs. Anaesthesia (in press)..Google Scholar
  12. 12.
    Gale, A. S. The Effect of Methylphenidate (Ritalin) on Thiopental Recovery. Anesthesiology.19: 521 (1958).PubMedCrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1960

Authors and Affiliations

  • Allen B. Dobkin
    • 1
  • John L. Pearson
    • 1
  • James S. Barr
    • 1
  1. 1.Department of AnaesthwsiaUniversity of Saskatchewan College of Medicine and Unersity HospitalSaskatoon, Sask.

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