RETRACTED ARTICLE: Prevention of PONV with granisetron, droperidol or metoclopramide in patients with postoperative emesis

  • Yoshitaka Fujii
  • Yuhji Saitoh
  • Hiroyoshi Tanaka
  • Hidcnori Toyooka
Reports of Investigation



A high incidence of postoperative nausea and vomiting (PONV) has been noted in patients with a history of postoperative emesis. This study was undertaken to compare the efficacy of granisetron, droperidol and metoclopramide, in the prevention of PONV in such patients undergoing general anaesthesia for major gynaecological surgery.


In a randomised, double-blind study, 90 female patients received 2.5 mg granisetron, 1.25 mg droperidol or 10 mg metoclopramide (n = 30 of each)iv immediately before induction of anaesthesia. The same standard general anaesthetic technique, which consisted of isoflurane in nitrous oxide and oxygen, was used. Nausea, vomiting and safety assessments were performed continuously during the first 24 hr after anaesthesia.


The incidence of PONV was 20% with granisetron, 57% with droperidol and 60% with metoclopramide (P < 0.05; overall Fisher’s exact probability test). No clinically adverse events were observed in any group.


Granisetron is more effective than droperidol or metoclopramide in preventing PONV in female patients with a history of postoperative emesis.


Metoclopramide Granisetron Droperidol Motion Sickness Domperidone 
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Les patientes présentant une histoire de vomissements post opératoires ont une incidence élevée de nausées/vomissements post opératoires (NVPO). Le but de cette étude est de comparer l’efficacité du granisétron, du dropéridol et du métoclopramide en prévention des NVPO chez de tels patientes soumises à une anesthésie générale pour chirurgie gynécologique majeure.


Dans une étude aléatoire et à double insu, 90 patientes ont reçu par voie I.V 2,5 mg de granisétron, 1,25 mg de dropéridol ou 10 mg de métoclopramide (n = 30 chaque groupe) immédiatement avant l’induction de l’anesthésie. La technique d’anesthésie générale consistait en isoflurane, N2O,O2 et était la même pour toutes les patientes. Lévaluation des nausée/vomissements et la surveillance ont été réalisées de façon continue durant le premier 24 heures.


L’incidence des NVPO étart de 20% avec le granisétron, 57% avec le dropéridol et 60% avec le métoclopramide (P < 0,05 test de Fisher exact). Aucun effet secondaire indésirable n’a été observé dans les trois groupes.


Le granisétron est plus efficace que le droperidol ou le métoclopramide dans la prévention des NVPO chez des patientes avec histoire de vomissements post opératoires.


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Copyright information

© Canadian Anaesthesiologists 1998

Authors and Affiliations

  • Yoshitaka Fujii
    • 1
  • Yuhji Saitoh
    • 2
  • Hiroyoshi Tanaka
    • 3
  • Hidcnori Toyooka
    • 1
  1. 1.Department of AnaesthesiologyUniversity of Tsukuba Institute of Clinical MedicineTsukuba City, IbarakiJapan
  2. 2.Department of Anaesthesiology and Critical Care MedicineTokyo Medical and Dental University School of MedicineBunkyo-ku, TokyoJapan
  3. 3.Department of AnaesthesiologyToridc Kyodo General HospitalToridc City, IbarakiJapan

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