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Effects of caudal block with mepivacaine on resting ventilation and ventilatory response to carbon dioxide in sedated children

  • Mayumi Takasaki
  • Yoshihiro Kosaka
Article

Abstract

We examined the effects of caudal anaesthesia using JO mg.kg-1 of one or two per cent mepivacaine without epinephrine on resting ventilation, arterial blood gas tensions and the ventilatory response to carbon dioxide in 27 sedated children. Expired minute volume and respiratory frequency decreased significantly after the caudal blocks in both groups. PaO2 and PaCO2 remained unchanged in both groups. The slope of the CO2 response curve increased significantly in both groups. The mean plasma mepivacaine levels were 4.6 ± 1.6 (SD) and 4.6 ± 1.0 µg.ml-1 20 minutes after the caudal blocks with one and two per cent mepivacaine, respectively. These results demonstrate that resting ventilation is impaired but the ventilatory response to carbon dioxide is improved similarly by caudal block with one or two per cent mepivacaine.

Key words

anaesthetic local mepivacaine anaesthetic technique caudal epidural ventilation paediatric carbon dioxide response 

Résumé

On a étudié les effets de ľanesthésie caudale utilisant 10 mg.kg-1 de un ou deux pour cent de mépivacaïne sans épinéphrine sur la ventilation au repos, la gazométrie artérielle et la réponse ventilatole au CO2 chez 27 enfants sous sédation. Le volume minute expiré et la fréquence respiratoire diminuèrent significativement après le bloc caudal avec les deux concentrations. La PaO2 et la PaCO2 demeurèrent inchangées dans les deux groupes. La pente de la courbe réponse au CO2 augmenta significativement après le bloc caudal aux deux concentrations. Les taux moyens plasmatiques de mépivacaïne étaient de 4.6 ±1.6 (SD) et 4.6 ±1.0 µg.ml-1 20 minutes après le bloc caudal avec un et deux pour cent de mépivacaïne respectivement. Les résultats démontrent que la ventilation au repos est altérée mais la réponse ventilatoire au CO2 est améliorée après bloc caudal avec un et deux pour cent de mépivcaïne.

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Copyright information

© Canadian Anesthesiologists 1988

Authors and Affiliations

  • Mayumi Takasaki
    • 1
  • Yoshihiro Kosaka
    • 1
  1. 1.Department of AnesthesiologyShimane Medical UniversityIzumoJapan

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