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Canadian Journal of Anaesthesia

, Volume 35, Issue 3, pp 255–258 | Cite as

Myalgia in outpatient surgery: comparison of atracurium and succinylcholine

  • Claude A. Trépanier
  • Claude Brousseau
  • Louise Laccrte
Article

Abstract

We studied 60 outpatients randomly divided into two groups. Anesthesia was induced withfentanyl 1.5 µg.kg-1 plus thiopentone 5-7 mg.kg-1. Patients in Group I were intubated with the aid of succinylcholine 1.5 mg.kg-1 after pre-treatment with d-tubocurarine 0.05 mg.kg-1, Group II received atracurium 350 µg.kg-1 three minutes after a priming dose of 50 µg.kg-1. Anesthesia was maintained with isoflurane 1-2 per cent in a mixture of nitrous oxide 60 per cent and oxygen 40 per cent. No supplemental doses of fentanyl or atracurium were given. Intubation conditions were satisfactory for all patients in both groups. There was no significant difference in intubation score between the two groups. The incidence of myalgia was 76 per cent in the succinylcholine group compared to 23 per cent in the atracurium group (p < 0.0005). Fifty per cent of the patients in the succinylcholine group had myalgia necessitating bed rest or analgesics compared to 23 per cent in the atracurium group (p < 0.05). We conclude that atracurium is a suitable neuromuscular relaxant for outpatient surgery and that myalgia is a major morbidity factor in this population that can be reduced by the use of atracurium instead of succinylcholine.

Key words

Neuromuscular relaxants Succinylcholine atracurium SURGERY outpatient Intubation tracheal Complications myalgia 

Résumé

Nous avons étudié 60 patients en chirurgie ďun jour attribués de façon aléatoire à deux groupes. Ľanesthésie fut induite avec du fentanyl 1.5 µg.kg-1 et du thiopental 5-7 mg.kg-1. Les patients du groupe I furent intubés avec de la succinylcholine 1.5 mg.kg-1 précédée de d-tubocurarine 0.05 mg.kg-1 et ceux du groupe II avec de ľatracurium 350 µg-kg-1 après une dose ďamorçage de 50 µg-kg-1. Le maintien de ľanesthésie consistait ďisoflurane 1 -2 pour cent dans un mélange de protoxide ďazote 60 pour cent et oxygène 40 pour cent. Aucun supplément de fentanyl ou ďatracurium ne fut administré. Les conditions ďintubation furent satisfaisantes pour tous les patients. Il n’y avait pas de différence significative entre les deux groupes. Ľincidence des myalgies fut de 76 pour cent dans le groupe succinylcholine comparé à 23 pour cent pour ľatracurium (p < 0.0005). De plus, 50 pour cent des patients ayant reçu de la succinylcholine durent garder le lit ou prendre des analgésiques contre 23 pour cent avec ľatracurium (p < 0.05), Nous concluons que ľatracurium est une alternative valable comme relaxant en chirurgie ďun jour et que les myalgies représentent une source importante de morbidité que peut être atténuée par ľemploi ďatracurium.

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Copyright information

© Canadian Anesthesiologists 1988

Authors and Affiliations

  • Claude A. Trépanier
    • 1
  • Claude Brousseau
    • 1
  • Louise Laccrte
    • 1
  1. 1.Department of AnesthesiaHôpital de ľEnfant-Jésus, Université LavalQuébec

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