Canadian Anaesthetists’ Society Journal

, Volume 28, Issue 5, pp 453–458 | Cite as

Epidural morphine and post-operative pain relief

  • A. J. C. Holland
  • S. K. Srikantha
  • J. A. Tracey


Epidural morphine was compared with placebo in two randomly selected but similar groups of patients undergoing upper abdominal operations. There was no quantitative or qualitative difference in the analgesia obtained in the two groups of patients but there were significantly diminished long term requirements of intramuscular morphine in those who had been previously given epidural morphine when compared with epidural placebo. The possible causes and implications of this difference are discussed.

Key Words

Epidural Morphine Post-Operative Analgesia Placebo 


Le soulagement de la douleur produit par l’administration de morphine ou par celle d’un placebo par voie péridurale a été comparé chez deux groupes de patients soumis à une chirurgie abdominale dans le cadre d’une étude à double insu. On n’a pas observé de différence significative du degré d’analgésie obtenue entre les deux groupes de patients, mais les besoins à long terme de morphine intra-musculaires ont été significativement moindres chez les sujets ayant recu la morphine par voie péridurale que chez ceux ayant recu le placebo. Les causes possibles et les implications de ces résultats sont discutées.


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Copyright information

© Canadian Anesthesiologists 1981

Authors and Affiliations

  • A. J. C. Holland
    • 1
  • S. K. Srikantha
    • 2
    • 4
  • J. A. Tracey
    • 3
  1. 1.Department of AnaesthesiaThe Montreal General Hospital, McGill UniversityCanada
  2. 2.Department of AnaesthesiaThe Montreal General Hospital, McGill UniversityCanada
  3. 3.Department of AnaesthesiaThe Montreal General Hospital, McGill University. The Montreal General HospitalMontreal
  4. 4.Department of AnaesthesiaEast Birmingham HospitalBirminghamEngland

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