Prostaglandins and anaesthesia

  • C. H. Kehler


Since their discovery, the eicosanoids have been found to have a role in an increasing number of clinically important areas. In anaesthesia and intensive care, the study of the eicosanoids in the pathophysiology and treatment of various clinical problems is very recent. It is hoped that this review, along with the reference articles, will provide a basis on which to add some of the new information which is rapidly becoming available.


Arachidonic Acid PGE2 Prostacyclin Eicosanoid PGI2 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Recommended Reading List

  1. 1.
    Watkins WD, Kehler CH. Prostaglandins: Importance to anesthesia. ASA Refresher Courses in Anesthesiology 1981 ; 9: 203–212.CrossRefGoogle Scholar
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    Moncada S, Vane JR. Arachidonic acid metabolites and the interactions between plate[ets and blood vessel walls. N Engl J Med 1979; 300:1142–1147,PubMedCrossRefGoogle Scholar
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    Tuvemo T. Role of prostaglandins, prostacyclin and thromboxanes in the control of the umbilicalplacental circulation, Sere Perinatol 1980; 4: 91–5.Google Scholar
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    Levin DL. Effects of inhibition of prostaglandin synthesis on fetal development, oxygenation and the fetal circulation. Sere Perinatol 1980; 4: 35–44.Google Scholar
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    Seale JP. Prostaglandins, slowreactingsubstances (leukotrienes) and the lung. Aust NZ J Med 1981; 11: 550–557.CrossRefGoogle Scholar
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    Goetzl El. Oxygenation products of arachidonic acid as mediators of hypersensitivity and inflammation. Med Clin N Am 1981;65: 809–828.Google Scholar
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    Nasfletti A, Malik KU. Interrelations between prostaglandins and vasoconstrictor hormones: contribution to blood pressure regulation. Fed Proc 1982; 41: 2394–2349.Google Scholar
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    Harlan JN, Harker HA. Hemostasls, thrombosis, and thromboembolic disorders. The role of arackidonic acid mctabolitcs in platelebvessel wall interactions. Med Clin N Am 1981 ; 65: 855–880.PubMedGoogle Scholar
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    Demling RH. Rote of prostaglandms in acute pulmonary microvascular injury. Ann N Y Acad Sci 1982; 384: 517–34.PubMedCrossRefGoogle Scholar
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    Olley PM, Coceani F. Use ofprostaglandins in cardiopulmonary diseases of the newborn. Sem Perinatol 1980; 4: 135–141.Google Scholar
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    Longmore DB, Bennett JG, Hoyle PM et al. Prostacyclin infusion during cardiopulmonary bypass in man. Lancet 1981; 1: 800–4.PubMedCrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1983

Authors and Affiliations

  • C. H. Kehler
    • 1
  1. 1.Department of AnaesthesiaUniversity of Manitoba, Health Sciences CentreWinnipeg

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