Hepatic circulation and hepatic function during anaesthesia and surgery II the effect of various anaesthetic agents

  • A Galindo


The effects of various anaesthetic agents on the hepatic and the systemic circulation were observed simultaneously Chloroform and carbon tetrachloride produced the greatest hepatic circulatory depression, with no recovery after two hours of administration Ether and N2O had no heplatic circulatory effect Cyclopropane increased hepatic aitery vascular resistance Halothane and total sympathetic block depressed the hepatic circulation in a manner which paralleled the systemic circulatory depression, there was immediate recovery after cyclopropane or sympathetic block, after halothane, recovery was slower.

These studies suggest that the impairment of the hepatic circulation during anaesthesia and surgery may be important m the development of post-surgical hepatic necrosis Anaesthetic drugs can produce various degrees of hepatic circulatory depression, but they are not the only aetiological factor, nor does the depression affect only the circulation of the liver.


Halothane Hepatic Artery Carbon Tetrachloride Cyclopropane Pentothal 
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Nous avons observé, simultanément sur la circulation hépatique et sur la circulation systémique, les effets des différents agents anesthésiques Ce sont le chloroforme et le tétrachlorure de carbone qui entraînent la plus grande dépresrsion circulatoire hépatique qui, après deux heures d’administration, demeure irréversible. L’éther et le protoxyde d’azote n’ont pas d’effet circulatoire hépatique Le cyclopropane augmente la résistance vasculaire de l’artère hépatique, l’halothane et le blocage sympathique complet affectent la circulation hépatique au même point que la circulation systémique Après le cyclopropane et le blocage sympathique il se fait un retour rapide à la normale, tandis qu’après l’halothane le retour est plus lent

Ces études nous rappellent que les changements de la circulation hépatique, au cours de l’anesthésie et de la chirurgie, peuvent être un facteur important dans l’apparition de la nécrose hépatique postopératoire Les agents anesthésiques peuvent produire différents degrés de dépression de la circulation hépatique, mais ils ne sont pas le seul facteur étiologique et cette dépression circulatoire ne touche pas le foie seulement


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Copyright information

© Canadian Anesthesiologists 1965

Authors and Affiliations

  • A Galindo
    • 1
  1. 1.Department of Neurology and NeurosurgeryMcGill University and the Montreal Neurological Institute and HospitalCanada

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