Canadian Journal of Anaesthesia

, Volume 34, Issue 1, pp 14–16 | Cite as

Effects of anaesthesia and surgery on the solubility of volatile anaesthetics in blood

  • Jerrold Lerman
  • George A. Gregory
  • Edmond I. Eger II


To determine the effects of anaesthesia and surgery on the solubility of volatile anaesthetics in blood, we measured the blood/gas partition coefficients of enflurane, halothane, isoflurane, and methoxyflurane in vitro in blood obtained from six healthy unpremedicated adults at three different times during isoflurane anaesthesia: (1) awake; (2) 20 minutes after induction of anaesthesia, but before surgical incision; and, (3) 90 minutes after surgical incision. The blood/gas partition coefficients of the four volatile anaesthetics decreased significantly after induction of anaesthesia and after surgical incision (p < 0.05). Values for haematocrit and the serum concentrations of albumin, globulin, and cholesterol decreased parallel to the decrease in blood/gas partition coefficients.


Isoflurane Halothane Partition Coefficient Enflurane Volatile Anaesthetic 
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Afin de déterminer les effets de ľanesthésie et de la chirurgie sur la solubilité des anesthésiques volatiles dans le sang, on a mesuré les coefficients de partition sang/gaz de ľenflurane, halothane, isoflurane, et méthoxyflurane in vitro dans le sang obtenu de six adultes non prémédiqués trois temps différents lors de ľanesthésie à ľisoflurane: 1) réveil, 2) 20 minutes après ľinduction de ľanesthésie mais avant ľincision chirurgicale et 3) 90 minutes après ľincision chirurgicale. Les coefficients de partition sanglgaz des quatre anesthésiques volatiles diminuèrent significativement après induction de ľanesthésie et après incision chirurgicale (p < 0.05,1. Les valeurs de ľhématocrite, ľalbumine sérique, la globuline ainsi que le cholestérol ont diminué parallèlement à la diminution des coefficients de partition sanglgaz.


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Copyright information

© Canadian Anesthesiologists 1987

Authors and Affiliations

  • Jerrold Lerman
    • 1
    • 2
  • George A. Gregory
    • 1
  • Edmond I. Eger II
    • 1
  1. 1.Departments of Anesthesia and Pediatrics, and the Cardiovascular Research InstituteUniversity of CaliforniaSan Francisco
  2. 2.Department of AnaesthesiaThe Hospital for Sick Children, 555 University AvenueToronto

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