Comparison of the calming and sedative effects of nalbuphine and pentazocine for paediatric premedication

  • Lucida Rita
  • Frank Seleny
  • Mashallah Goodarzi


Nalbuphine (EN2234A) is an agonist-antagonist analgesic. It is structurally related to the narcotic analgesic oxymorphone and to the narcotic antagonist naloxone. A double blind study was carried out in 400 children in ASA classification I, ranging from 10 months to 14 years of age, to compare nalbuphine, pentazocine and placebo for paediatric premedication. Our results showed that nalbuphine is comparable to pentazocine as a premedicating agent and superior to placebo, in the doses used, and that premedication is an important adjunct to anaesthesia in children. Following premedication with nalbuphine or pentazocine, there were fewer apprehensive children at the time of induction of anaesthesia and in the recovery room when compared to those receiving placebo injections.


Morphine Naloxone Recovery Room Pentazocine Nalbuphine 
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La nalbuphine (EN2234A) est un analgésique du type agoniste-antagoniste. Sa structure s’apparente à celle du narcotique analgésique oxymorphone et à celle du narcotique antagoniste naloxone. Elle a été comparée à la pentazocine et à un placebo comme agent de prémédication dans le cadre d’une étude à double insu conduite chez 400 enfants en bon état général (classe I de I’ASA) et âgès de 10 mois à 14 ans. Nos résultats ont montré qu’elle est comparable à la pentazocine et supérieure au placebo comme agent de prémédication. Us ont également fait ressortir 1’importance de la prémédication enanesthésie pédiatrique, le nombre d’enfants anxieux au moment de l’induction de l’anesthésie et dans la salle de réveil, étant inférieur à celui trouvé chez ceux ayant reçu le placebo.


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Copyright information

© Canadian Anesthesiologists 1980

Authors and Affiliations

  • Lucida Rita
    • 1
  • Frank Seleny
    • 1
  • Mashallah Goodarzi
    • 1
  1. 1.Children’s Memorial HospitalNorthwestern University Medical SchoolChicago

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