Physostigmine reversal of postoperative somnolence

  • Gary E. Hill
  • Theodore H. Stanley
  • Craig R. Sentker


The effects of physostigmine on reversal of post-operative somnolence following general anaesthesia were evaluated in 187 patients. Significant reversal of anaesthetic-induced post-operative somnolence was observed in those patients receiving physostigmine when compared to a control group. These results suggest that general anaesthesia with halothane may be included in those situations where central nervous system depression may be reversed by administration of physostigmine. Cholinergic side-effects observed with physostigmine administration were minimal.


Halothane Recovery Room Physostigmine Verbal Command Central Nervous System Depression 
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RéSUMé Ľinfluence de la physostigmine sur ľéveil de ľanesthésie a été évaluée chez cent patients en bonne santé (classe I — ASA). Comparés à un groups contrôle de 87 malades, les patients ayant reçu de la physostigmine ont résupéré plus rapidement de ľétat de somnolence secondaire à ľanesthésie générale.

Ces résultats suggèrent que la physostigmine peut renverser ľétat de somnolence secondaire à une anesthésie générale.


  1. 1.
    Rumack, B.H. Anticholinergic poisoning: treatment with physostigmine. Pediatrics52: 449 (1973).PubMedGoogle Scholar
  2. 2.
    Heiser, J.F. &Gillin, J.C. The reversal of anticholinergic drug-induced delirium and coma with physostigmine. Am. J. Psychiatry127: 1050 (1971).PubMedGoogle Scholar
  3. 3.
    Bidwai, A.V., Cornelius, L.R., &Stanley, T.H. Reversal of innovar-induced postanesthetic somnolence and disorientation with physostigmine. Anesthesiology44: 249 (1976).PubMedCrossRefGoogle Scholar
  4. 4.
    Slovis, T.L., Ott, J.E., Teitelbaum, D.T., &Lipscomb, W. Physostigmine therapy in acute tricyclic antidepressant poisoning. Clin. Tox.4: 451 (1971).Google Scholar
  5. 5.
    El-Yousef, M.K., Janowsky, D.S., Davis, J.M., &Sekerke, H.J. Reversal of antiparkinsonian drug toxicity by physostigmine: a controlled study. Am. J. Psychiatry130: 141 (1973).PubMedGoogle Scholar
  6. 6.
    Hebb, O. CNS at the cellular level: identity of transmitter agents. Ann. Rev. Physiol.32; 165 (1970).CrossRefGoogle Scholar
  7. 7.
    Chalazonitis, N. Selective actions of volatile anesthetics on synaptic transmission and autorhythmicity in single identifiable neurons. Anesthesiology28: 111 (1967).PubMedCrossRefGoogle Scholar
  8. 8.
    Larrabee, M.G. &Posternak, J.M. Selective action of anesthetics on synapses and axons in mammalian sympathetic ganglia. J. Neurophysiol.15: 91 (1952).PubMedGoogle Scholar
  9. 9.
    Brebner, J. &Hadley, L. Experiences with physostigmine in the reversal of adverse post-anesthetic effects. Canad. Anaesth. Soc. J.23: 574 (1976).PubMedCrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1977

Authors and Affiliations

  • Gary E. Hill
    • 1
  • Theodore H. Stanley
    • 1
  • Craig R. Sentker
    • 1
  1. 1.Department of AnesthesiologyUniversity of Utah College of MedicineSalt Lake City

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