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Does supplementation of CT and MRI with gallium-67 SPECT improve the differentiation between benign and malignant tumors of the head and neck?

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Abstract

The objective of our study is to determine whether67Ga SPECT can supplement CT and/or MRI diagnostic information by visual comparison of the two separate data sets in patients with head and neck tumors.Methods: A total of 50 patients with head and neck tumors (benign: 19, malignant: 31) were entered in the study. Three board-certified radiologists who had practical experience in interpreting both head and neck CT/MRI and67Ga SPECT images, participated as readers. All of the CT and/or MR images of each patient were shown to each reader first, who after they had finished interpreting them were shown the67Ga SPECT images. They were asked to score each image on a 7-point scale for the likelihood of the presence or absence of malignancy. Histological or cytological evaluation was done in all cases, and the radiologic studies were correlated with these findings.Results: Improvement of all three readers’ performance was from 70.7% to 83.3% in the mean accuracy and from 0.790 to 0.921 in the mean Az value (p=0.033, 0.163, 0.105 in the Az values) after they were shown the67Ga SPECT images.Conclusions:67Ga SPECT should substantially increase confidence in the diagnosis of head and neck tumors when CT and/or MRI do not permit differentiation between benign and malignant disease.

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References

  1. Dillehay GL, Papatheofanis F. Gallium imaging of tumors. In: Henkin RE, Boles MA, Dillehay GL, eds.Nuclear Medicine. St. Louis: Mosby-Year Book, Inc., 1996; 1463–1492.

    Google Scholar 

  2. Kostakoglu L, Yeh SDJ, Portlock C, et al. Validation of gallium-67-citrate single photon emission tomography in biopsy-confirmed residual Hodgkin’s disease in the mediastinum.J Nucl Med 1992; 33: 345–350.

    PubMed  CAS  Google Scholar 

  3. Front D, Bar-Shalom R, Mor M, Haim N, Epelbaum R, Frenkel A, et al. Hodgkin disease: prediction of outcome with67Ga scintigraphy after one cycle of chemotherapy.Radiology 1999; 210: 487–491.

    PubMed  CAS  Google Scholar 

  4. Front D, Bar-Shalom R, Mor M, Haim N, Epelbaum R, Frenkel A, et al. Aggressive non-Hodgkin lymphoma: early prediction of outcome with67Ga.Radiology 2000; 214: 253–257.

    PubMed  CAS  Google Scholar 

  5. Murata Y, Ishida R, Umehara I, Ishikawa N, Komatsuzaki A, Kurabayashi T, et al.67Ga whole-body scintigraphy in the evaluation of head and neck squamous cell carcinoma.Nucl Med Commun 1999; 20: 599–607.

    Article  PubMed  CAS  Google Scholar 

  6. Tomura N, Hirano H, Watanabe O, Hirano Y, Kato K, Sasaki K, et al. Comparison of thallium-201 and gallium-67 imaging in evaluation of head and neck tumors.J Comput Assist Tomogra 2000; 24: 454–460.

    Article  CAS  Google Scholar 

  7. American Joint Committee on Cancer. Staging of cancers at specific anatomic sites: lip and oral cavity. In: Bearths OH, Henson D, Hutter RVP, Myers MH, eds.Manual for Staging of Cancer, 3rd ed. Philadelphia; Lippincott, 1988; 27–32.

    Google Scholar 

  8. Hanley JA, McNeil. The meaning and use of the area under a receiver operating characteristics (ROC) curve.Radiology 1982; 143: 29–36.

    PubMed  CAS  Google Scholar 

  9. Zbaren P, Becker M, Lang H. Pretherapeutic staging of laryngeal carcinoma: clinical findings, computed tomography, and magnetic resonance imaging compared with histopathology.Cancer 1996; 77: 1263–1273.

    Article  PubMed  CAS  Google Scholar 

  10. Zbaren P, Becker M, Lang H. Pretherapeutic staging of hypopharyngeal carcinoma: clinical findings, computed tomography, and magnetic resonance imaging compared with histopathologic evaluation.Arch Otolaryngol Head Neck Surg 1997; 123: 908–913.

    PubMed  CAS  Google Scholar 

  11. Castelijns JA, Becker M, Hermans R. Impact of cartilage invasion on treatment and prognosis of laryngeal cancer.Eur Radiol 1996; 6: 156–169.

    Article  PubMed  CAS  Google Scholar 

  12. Jabour BA, Choi Y, Hoh CK, Rege SD, Soong JC, Lufkin RB, et al. Extracranial head and neck: PET imaging with 2-[F-18]fluoro-2-deoxy-d-glucose and MR imaging correlation.Radiology 1993; 186: 27–35.

    PubMed  CAS  Google Scholar 

  13. Li P, Zhuang H, Mozley PD, Denittis A, Yeh D, Machtay M, et al. Evaluation of recurrent squamous cell carcinoma of the head and neck with FDG positron emission tomography.Clin Nucl Med 2001; 26: 131–135.

    Article  PubMed  CAS  Google Scholar 

  14. Chisin R, Pietrzyk U, Sichel JY, Rubinstein R, Yaffe S, Bocher M, et al. Registration and display of multi-modal images: applications in the extracranial head and neck region.J Otolaryngol 1993; 22: 214–219.

    PubMed  CAS  Google Scholar 

  15. Treves ST, Mitchell KD, Habboush IH. Three-dimensional image alignment, registration and fusion.J Nucl Med 1998; 42: 83–92.

    CAS  Google Scholar 

  16. Bocher M, Balan A, Krausz Y, Shrem Y, Lonn A, Wilk M, et al. Gamma camera-mounted anatomical X-ray tomography: technical, system characteristics and first images.Eur J Nucl Med 2000; 27: 619–627.

    Article  PubMed  CAS  Google Scholar 

  17. Tsan M, Scheffel U. Mechanism of gallium-67 accumulation in tumors.J Nucl Med 1986; 27: 1215–1219.

    PubMed  CAS  Google Scholar 

  18. Vaughan CW, FitzGerald TJ, Vlock D, Vergo TJ Jr, Costello R. Cancer of the head and neck. In: Osteen RT, ed.Cancer Manual 9th ed. Boston; American Cancer Society, 1996: 290–307.

    Google Scholar 

  19. Okumura Y, Takeda Y, Sato S, Komatsu M, Nakagawa T, Akaki S, et al. Comparison of differential diagnostic capabilities of201Tl scintigraphy and fine-needle aspiration of thyroid nodules.J Nucl Med 1999; 40: 1971–1977.

    PubMed  CAS  Google Scholar 

  20. Togawa T, Suzuki A, Kato K, Higuchi Y, Moriya H, Hoshi K, et al. Relationship between201Tl to67Ga uptake ratio and histological type in primary lung cancer.Eur J Cancer and Clinical Oncol 1985; 21: 925–930.

    Article  CAS  Google Scholar 

  21. Togawa T, Yui N, Kinoshita F, Koakutsu M, Ishihara M. Tl-201/Ga-67 uptake ratio in lung tumors—comparison between planar and SPECT methods.KAKU IGAKU (Jpn J Nucl Med) 1992; 29: 123–131.

    CAS  Google Scholar 

  22. Mukherji SK, Drane WE, Tart RP, Landau S, Mancuso AA. Comparison of thallium-201 and F-18 FDG SPECT uptake in squamous cell carcinoma of the head and neck.AJNR 1994; 15: 1837–1842.

    PubMed  CAS  Google Scholar 

  23. Valdes Olmos RA, Balm AJ, Hilgers FJM, Koops W, Loftus BM, Tan IB, et al. Thallium-201 in the diagnosis of head and neck cancer.J Nucl Med 1997; 38: 873–879.

    Google Scholar 

  24. Nagamachi S, Hoshi H, Jinnouchi S, Ohnishi T, Flores LG, Futami S, et al. Tl-201 SPECT for evaluation for head and neck cancer.Ann Nucl Med 1996; 10: 105–111.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Japan

    Shigeru Kosuda, Yoshiko Kadota, Satoshi Umeda & Shoichi Kusano

  2. Department of Radiology, Keio University School of Medicine, Keio, Japan

    Hiroshi Fujii

  3. Department of Health, Yamaguchi University School of Medicine, Yamaguchi, Japan

    Kiyoshi Ichihara

Authors
  1. Shigeru Kosuda
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  2. Yoshiko Kadota
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  3. Satoshi Umeda
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  4. Shoichi Kusano
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  5. Hiroshi Fujii
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  6. Kiyoshi Ichihara
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Correspondence to Shigeru Kosuda.

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Kosuda, S., Kadota, Y., Umeda, S. et al. Does supplementation of CT and MRI with gallium-67 SPECT improve the differentiation between benign and malignant tumors of the head and neck?. Ann Nucl Med 17, 475–480 (2003). https://doi.org/10.1007/BF03006438

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  • DOI: https://doi.org/10.1007/BF03006438

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