Thallium-201 brain SPECT to diagnose aggressiveness of meningiomas
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This investigation was conducted to determine the ability of201Tl brain SPECT with respect to preoperative prediction of lesional aggressiveness of meningioma. Fifty-nine lesions in 42 patients were examined. Early (15 min) and late (3h) SPECT were obtained. Early uptake ratio (ER; lesion to normal brain average count ratio), late uptake ratio (LR) and the ratio of LR to ER (L/E ratio) were calculated. Twenty-three lesions exhibited malignant features based on histologic or clinical course such as recurrence or skull invasion. Both ER and LR of malignant meningiomas were significantly higher than those in thirty-six benign lesions. Benign lesions were classified into two groups for further analysis: meningotheliomatous type, which is the most common histology, and benign lesions other than the meningotheliomatous (other benign) type. ER in other benign type was lower than the meningotheliomatous and the malignant type. LR afforded differentiation of the malignant type from the two benign types. These two benign types could be distinguished on the basis of the L/E ratio. These results indicate that high pre-operative ER and LR values in patients with meningioma are indicators of the aggressiveness of lesions, i.e., malignant meningioma, recurrence or skull invasion.
Key wordsthallium-201 imaging brain SPECT meningioma
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- 18.Sugo N, Kuroki T, Nemoto M, Mito T, Seiki Y, Shibata I. Difference in Tl-201 accumulation mechanism in brain tumors: A comparison of their Na+-K+ ATPase activities.KAKU IGAKU (Jpn J Nucl Med) 2000; 37: 311–318.Google Scholar
- 21.Lamszus K, Lengler U, Schmidt NO, Stavrou D, Ergun S, Westphal M. Vascular endothelial growth factor, hepatocyte growth factor/scatter factor, basic fibroblast growth factor, and placenta growth factor in human meningiomas and their relation to angiogenesis and malignancy.Neurosurgery 2000; 46: 938–947.PubMedCrossRefGoogle Scholar