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Annals of Nuclear Medicine

, Volume 17, Issue 6, pp 435–438 | Cite as

Usefulness of technetium-99m hexamethylpropylene amine oxime lung scan to detect inhalation lung injury of patients with pulmonary symptoms/signs but negative chest radiograph and pulmonary function test findings after a fire accident—a preliminary report

  • Yu-Chien Shiau
  • Feng-Yuan Liu
  • Jeffrey J. P. Tsai
  • Jhi-Joung Wang
  • Shung-Tai Ho
  • Albert Kao
Original Articles

Abstract

Objective: In this study, we employed technetium-99m hexamethylpropylene amine oxime (99mTc HMPAO) lung scan to detect inhalation lung injury of patients after a fire accident.Methods: Ten healthy men for controls and 10 male patients with pulmonary symptoms/signs from a fire accident were enrolled in this study for comparison.99mTc HMPAO lung scan was performed in each control and patient, as well as the degree of pulmonary vascular endothelium damage was represented as lung/liver uptake ratios (L/L ratio). All of the controls and patients had no smoking histories. None of the controls and patients had positive findings of plain chest radiograph (CXR) and pulmonary function test (PFT).Results: The results showed that significantly higher L/L ratio in the 10 patients (0.53±0.07) than in the 10 controls (0.30±0.07) (the p value<0.05). Using a cut-off value of 0.40, all of the 10 patients had abnormally increased L/L ratios.Conclusions: We conclude that99mTc HMPAO lung scan has the potential to be a sensitive, objective and noninvasive method to detect inhalation lung injury of patients with pulmonary symptoms/signs but negative CXR and PFT findings after a fire accident.

Key words

technetium-99m hexamethylpropylene amine oxime inhalation lung injury fire accident 

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Copyright information

© Springer 2003

Authors and Affiliations

  • Yu-Chien Shiau
    • 1
  • Feng-Yuan Liu
    • 1
  • Jeffrey J. P. Tsai
    • 2
  • Jhi-Joung Wang
    • 3
  • Shung-Tai Ho
    • 4
  • Albert Kao
    • 5
  1. 1.Department of Nuclear MedicineFar Eastern Memorial HospitalTaipeiTaiwan
  2. 2.Graduate Institute of BioinformaticsTaichung Healthcare and Management UniversityTaichungTaiwan
  3. 3.Department of Medical ResearchChi-Mei Medical CenterTainanTaiwan
  4. 4.School of MedicineNational Defense Medical CenterTaipeiTaiwan
  5. 5.Department of Medical ResearchChina Medical University HospitalTaichungTaiwan

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