Canadian Anaesthetists’ Society Journal

, Volume 24, Issue 2, pp 243–251 | Cite as

The effects of repeated14C halothane exposure in mice

  • W. W. Stoyka
  • G. Havasi


Halothane Repeated Exposure Mitochondrial Pellet Chamber Concentration Halothane Hepatitis 
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  1. 1.
    Cohen, E.N. &Hood, N. Application of low-temperature autoradiography to studies of the uptake and metabolism of volatile anaesthetics in the mouse III. Halothane. Anesthesiology31: 553–559 (1969).CrossRefGoogle Scholar
  2. 2.
    Van Dyke, R.A. &Wood, C.L. Binding of radioactivity from14C-labelled halothane in isolated perfused rat livers. Anesthesiology38: 328–332 (1973).PubMedGoogle Scholar
  3. 3.
    Cohen, E.N. Metabolism of Halothane-214C in the mouse. Anesthesiology31: 560–565 (1965).CrossRefGoogle Scholar
  4. 4.
    Topham, J.C. &Longshaw, S. Studies with halothane: I The distribution and excretion of halothane metabolites in animals. Anesthesiology37: 311–323 (1972).PubMedCrossRefGoogle Scholar
  5. 5.
    Stevens, W.C., Eger, E.I., White, A., Halsey, M.J., Munger, W., Gibbons, R.D., Dolan W. &Shargel R. Comparative toxicities of halothane, isoflurane, and diethyl ether at subanesthetic concentrations in laboratory animals. Anesthesiology42: 408–419 (1975).PubMedCrossRefGoogle Scholar
  6. 6.
    Sawyer, D.C., Eger, E.I., Bahlam, S.H., Cullen, B.F., &Impelman, A.B. Concentration dependence of hepatic halothane metabolism. Anesthesiology34: 230–235 (1971).PubMedCrossRefGoogle Scholar
  7. 7.
    Sedgwick, B. &Hubscher, G. Metabolism of phospholipids IX Phosphatidate phosphohy-drolase in rat liver, Biochima et Biophysica Acta106: 63–77 (1965).Google Scholar
  8. 8.
    Kamath, S.A. &Rubin, E. The exchange of phospholipids between subcellular organelles of the liver. Archives of Biochemistry and Biophysics158: 312–322 (1973).PubMedCrossRefGoogle Scholar
  9. 9.
    Takahashi, S., Shigematsu, A., &Furukawa, T. Interaction of volatile anaesthetics with rat microsomal cytochrome P-450. Anesthesiology41: 375–379 (1974).PubMedCrossRefGoogle Scholar
  10. 10.
    Ross, L.M. The cell. Ciba Clinical Symposia26: #3, I-35 (1974).Google Scholar
  11. 11.
    Cohen, E.N. &Trudell, J.R. Nonvolatile metabolites of halothane. Cellular biology and toxicity of anaesthetics. Edited by Fink, B.R. Baltimore: Williams and Wilkins, 205–214 (1972).Google Scholar
  12. 12.
    Rehder, K., Forbes, J., Alter, H., Hessler, C., &Stier, A. Halothane biotransformation in man: a quantitative study. Anesthesiology28: 711–715 (1967).PubMedCrossRefGoogle Scholar
  13. 13.
    Cascorbi, H.F., Blake, D.A., &Helrich, M. Differences in the biotransformation of halothane in man. Anesthesiology32: 119–123 (1970).PubMedCrossRefGoogle Scholar
  14. 14.
    Cohen, E.N., Trudell, J.R., Edmunds, H.N., &Watson, E. Urinary metabolites of halothane in man. Anesthesiology43: 392–401 (1975).PubMedCrossRefGoogle Scholar
  15. 15.
    Brown, B.R. Drugs, metabolism and toxicity. Audio digest Foundation. Anesthesiology18: 5 (March, 1976).Google Scholar
  16. 16.
    Inman, W.H.W. &Mushin, W.W. Jaundice after repeated exposure to halothane. An analysis of reports to the committee on the safety of medicines. Br. Med. J.1: 5–10 (1974).PubMedCrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1977

Authors and Affiliations

  • W. W. Stoyka
    • 1
  • G. Havasi
    • 1
  1. 1.Department of AnaesthesiaUniversity of Toronto, St. Michael’s HospitalTorontoCanada

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