Canadian Anaesthetists’ Society Journal

, Volume 24, Issue 2, pp 195–202 | Cite as

Double-blind evaluation of buprenorphine hydrochloride for post-operative pain

  • Allen B. Dobkin
  • Barbara Esposito
  • Carole Philbin

Summary and Conclusions

In a double-blind, random assignment study of four groups of 40 patients, relief of severe pain with buprenorphine hydrochloride 0.2 mg or 0.4 mg was evaluated and compared with morphine sulphate 5 or 10 mg. Evaluations included pain intensity, pain relief, sedation and other effects for up to 12 hours after drug administration, following recovery of wakefulness from anaesthesia for major abdominal surgery. Analyses of five parameters showed that the four groups were statistically comparable and that buprenorphine hydrochloride is at least 50 times more potent than morphine sulphate and has a substantially longer duration of analgesic action. Further clinical evaluation is, therefore, recommended.


Morphine Pain Intensity Buprenorphine CANADIAN Anaesthetist Pain Intensity Score 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Le chlorure de buprenorphine à des doses de 0.2 et de 0.4 mg a été comparée à la morphine à des doses de 5 et de 10 mg, ceci après éveil de ľanesthésie et suivant une chirurgie abdominale majeure.

Ľintensité de la douleur, son soulagement et la sédation produite, ainsi que les autres effets observés, ceci dans les 12 heures suivant ľadministration, ont été évalués.

Cette étude à double insu, portant sur une population volontaire de 160 malades, a permis de former quatre groupes au hasard, pour fins de comparaison des agents et des doses administrées.

Ľanalyse de nos résultats démontre que (1) nos quatre groupes étaient statis-tiquement comparables, (2) que le chlorure de buprenorphine est au moins 50 fois plus puissant que la morphine et (3) que son action est substantiellement plus longue.

On recommande la poursuite de son évaluation clinique.


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Copyright information

© Canadian Anesthesiologists 1977

Authors and Affiliations

  • Allen B. Dobkin
    • 1
  • Barbara Esposito
    • 1
  • Carole Philbin
    • 1
  1. 1.Department of AnesthesiologyState University of New York, Upstate Medical Center, State University HospitalNew YorkU.S.A.

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