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Canadian Anaesthetists’ Society Journal

, Volume 25, Issue 4, pp 297–302 | Cite as

Amnesie et autres effets du diazepam dans la premedication et l’induction de l’anesthesie

  • L. Authier
  • R. Chapados
  • A. Sindon
  • M. -A. Gagnon
Article

Summary

In this double-blind study, the effects of diazepam (0.15 mg/kg intramuscularly for premedication and 0.3 mg/sec intravenously for induction) on memory were compared to those of standard premedication and induction agents, meperidine (1 mg/kg) and thiopentone (2.5 mg/sec). Forty patients (32 females and 8 males), in physical status I, undergoing minor elective operations, received an auditory stimulus immediately before induction of anaesthesia; stimulus recall as well as subjective side-effects were assessed the following day. The volunteers were randomly assigned to either of two groups, each receiving one of the premedicaments. The two groups were further subdivided into sub-groups corresponding to the induction agents and intubation.

As a premedicant, diazepam produced more anterograde amnesia than meperidine without inducing any undesirable effect. Our results suggest that diazepam as an induction agent could possibly produce retrograde amnesia. The amnesic effects were more pronounced when diazepam was used successively for premedication and induction. Diazepam prevented the sore throat of intubation better than thiopentone, though it induced more nausea and vomiting.

Keywords

Cote Thiopental Thiopentone Meperidine Induction Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Dans cette étude à double-insu, ľeffet du diazépam (0.15 mg/kg I.M. en prémédication et 0.3 mg/sec I.V. en induction) sur la mémoire est comparé aux effets ďagents de prémédication et ďinduction standards, la mépéridine (1 mg/kg) et le thiopental (2.5 mg/sec). Quarante patients (32 femmes et 8 hommes), présentant un risque anesthésique de grade I et soumis à une chirurgie mineure élective, reçoivent un stimulus auditif immédiatement avant ľinduction anesthésique. La rétention mnémonique et les effets désirables ou indésirables subjectifs sont évalués le lendemain. Les volontaires sont répartis au hazard en deux groupes recevant ľune ou ľautre prémédication. Chacun de ces groupes est de plus subdivisé en deux sous-groupes correspondant aux deux agents ďinduction. Ľabsence ou la présence ďintubation détermine un niveau ultérieur de subdivision aléatoire.

En prémédication, le diazépam produit plus ďamnésie antérograde que la mépéridine sans induire ďeffets indésirables. Nos résultats laissent entrevoir la possibilité ďune amnésie rétrograde produite par le diazépam a ľinduction. Les effets sur la mémoire sont plus grands lorsque le diazépam est utilisé à la fois en prémédication et à ľinduction. Les maux de gorge de ľintubation sont moins fréquents avec le diazépam qu’avec le thiopental, mais le diazépam produit plus de nausées et de vomissements.

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Copyright information

© Canadian Anesthesiologists 1978

Authors and Affiliations

  • L. Authier
    • 1
  • R. Chapados
    • 1
  • A. Sindon
    • 1
  • M. -A. Gagnon
    • 2
  1. 1.Hôpital Maisonneuve-RosemontCanada
  2. 2.Département ďanesthésieHôpital Notre-DameMontréalCanada

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