A comparative assessment of alfathesin for use in outpatient anaesthesia

  • G. L. Dunn
  • P. J. Houlton
  • D. H. Morison
  • R. Rajagopalan


Alfathesin and thiopentone were compared in a double blind study where each drug was given by intravenous infusion supplemented with fentanyl and nitrous oxide, in 54 healthy female patients under-going therapeutic abortion. The two drugs were similar in terms of changes in cardiorespiratory variables, side effects, clinical efficacy, and patient acceptability. Alfathesin produced a significantly more rapid recovery from anaesthesia, without the high incidence of dreams found with thiopentone in this study. Alfathesin would seem to be the preferable drug for use in outpatients undergoing minor surgical operations.


Nitrous Oxide Thiopentone Potency Ratio Double Insu Anaesthetic Time 
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Dans le cadre ďune étude à double insu, 54 patients chez qui ľon procédait à un avortement thérapeutique ont reçu une infusion ďalfathesin, ou une infusion de thiopental supplémentée de protoxyde ďazote et de fentanyl.

Les modifications cardiorespiratoires, les effets secondaires, ainsi que ľefficacité clinique des deux agents ont été jugés similaires.

Ľéveil des patientes ayant reçu une perfusion ďalfathesin a cependant été plus rapide et ce de façon significative. Cet agent nous apparaît donc préférable dans les cas de chirurgie ambulatoire.


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Copyright information

© Canadian Anesthesiologists 1978

Authors and Affiliations

  • G. L. Dunn
    • 1
  • P. J. Houlton
    • 1
  • D. H. Morison
    • 1
  • R. Rajagopalan
    • 1
  1. 1.Department of AnaesthesiaMcMaster UniversityHamiltonCanada

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