Concentration of lidocaine hydrochloride in newborn gastric fluid after elective caesarean section and vaginal delivery with epidural analgesia

  • Sanjay Datta
  • Germain L. Houle
  • Gordon S. Fox


Lidocaine concentrations were measured after vaginal delivery or Caesarean section with epidural anaesthesia in samples of maternal and umbilical blood and in newborn gastric contents. The pH of the gastric aspirate was also determined in a number of neonates. Gastric lidocaine concentrations were higher and the pH was lower after vaginal delivery in comparison to Caesarean section. A significant inverse correlation exists between gastric pH and gastric lidocaine concentration. Neonate gastric lidocaine concentration was significantly higher than in maternal or umbilical venous plasma after vaginal delivery, but not after Caesarean section. Due to these differences, gastric lavage for the treatment of neonatal lidocaine intoxication may be more beneficial in reducing foetal systemic local anaesthetic concentration after vaginal than after elective abdominal delivery.


Lidocaine Caesarean Section Gastric Juice Vaginal Delivery Epidural Analgesia 
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Suivant un accouchement ou une césarienne sous anesthésie péridurale, la concentration de lidocaine a été estimée dans le sang de la mère et du cordon ombilicale ainsi que dans les secretions gastriques du nouveau-né. Le pH des sucs gastriques a aussi été évalué chez un certain nombre de nouveau-nés. La concentration gastrique de lidocaine a été plus élevée et le pH plus bas dans les accouchements que dans les césariennes. Une correlation inverse existe entre le pH des secretions gastriques et la concentration gastrique de lidocaine. La concentration gastrique de lidocaine était plus élevée de façon significative dans les échantillons sangins de la mère et de la veine ombilicale après l’accouchement mais non suivant une césarienne. A cause de ces différences, le lavage gastrique au pour le traitement de l’intoxication au lidocaine du neuveau-né serait plus efficace à diminuer la concentration systemique de l’anesthesique local après un accouchement que suivant une césarienne.


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Copyright information

© Canadian Anesthesiologists 1975

Authors and Affiliations

  • Sanjay Datta
    • 1
  • Germain L. Houle
    • 1
  • Gordon S. Fox
    • 1
  1. 1.Department of AnaesthesiaRoyal Victoria Hospital and McCill UniversityCanada

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