The effects of glucagon on the exocrine secretion of the perfused canine pancreas

  • J. J. Murphy
  • K. F. McGeeney


VOLUME, amylase, lipase and trypsin secretion in the totally isolated canine pancreas were studied. Glucagon does not have an inhibitory effect on the secretin or CCK-Pz evoked exocrine secretion of the isolated gland. In the gland stimulated by large combined doses of secretin and CCK-Pz, glucagon increases enzyme secretion. These findings may indicate that the inhibitory action of glucagon in the intact animal is indirect.


Lipase Glucagon Amylase Acute Pancreatitis Secretin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Ceska, M., Hultman, E. and Ingelman, B. G. A. 1969. A new method for the detemination of α-amylase. Experientia, 25, 555.PubMedCrossRefGoogle Scholar
  2. Condon, J. R., Knight, M. and Day, J. L. 1973. Glucagon therapy in acute pancreatitis. Brit. J. Surg., 60, 509.PubMedCrossRefGoogle Scholar
  3. Dyck, W. P., Rudick, J., Hoexter, B. and Janowitz, H. D. 1969. Influence of glucagon on pancreatic exocrine secretion. Gastroenterology, 56, 531.PubMedGoogle Scholar
  4. Dyck, W. P., Texter, E. C., Lasater, J. M. and Hightower, N. C. 1970. Influence of glucagon on pancreatic exocrine secretion in man. Gastroenterology, 58, 532.PubMedGoogle Scholar
  5. Erlanger, B. F., Kokowsky, N. and Cohen, W. 1961. The preparation and properties of two new chromogenic substrates of trypsin. Arch. Biochem., 95, 271.PubMedCrossRefGoogle Scholar
  6. Hubel, K. A. 1972. Secretin: A long progress note. Gastroenterology, 62, 318.PubMedGoogle Scholar
  7. Knight, M. J., Condon, J. R. and Smith, R. 1971. Possible use of glucagon in the treatment of pancreatitis. Brit. med. J., ii, 440.CrossRefGoogle Scholar
  8. Mutt, V. and Jorpes, E. 1971. Hormonal Polypeptides of the Upper Intestine. Biochem. J., 125, 57p.Google Scholar
  9. Nakajima, S. and Magee, D. F. 1970. Inhibition of exocrine pancreatic secretion by glucagon and D-glucose given intravenously. Canad. J. Physiol. Pharmacol., 48, 299.Google Scholar

Copyright information

© Springer 1974

Authors and Affiliations

  • J. J. Murphy
    • 1
  • K. F. McGeeney
    • 1
  1. 1.Departments of Surgery and of Medicine and TherapeuticsWoodview University CollegeDublin 4

Personalised recommendations