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The effects of glucagon on the exocrine secretion of the perfused canine pancreas

  • J. J. Murphy
  • K. F. McGeeney
Article

Summary

VOLUME, amylase, lipase and trypsin secretion in the totally isolated canine pancreas were studied. Glucagon does not have an inhibitory effect on the secretin or CCK-Pz evoked exocrine secretion of the isolated gland. In the gland stimulated by large combined doses of secretin and CCK-Pz, glucagon increases enzyme secretion. These findings may indicate that the inhibitory action of glucagon in the intact animal is indirect.

Keywords

Lipase Glucagon Amylase Acute Pancreatitis Secretin 
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References

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Copyright information

© Springer 1974

Authors and Affiliations

  • J. J. Murphy
    • 1
  • K. F. McGeeney
    • 1
  1. 1.Departments of Surgery and of Medicine and TherapeuticsWoodview University CollegeDublin 4

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