The effects of glucagon on the exocrine secretion of the perfused canine pancreas
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VOLUME, amylase, lipase and trypsin secretion in the totally isolated canine pancreas were studied. Glucagon does not have an inhibitory effect on the secretin or CCK-Pz evoked exocrine secretion of the isolated gland. In the gland stimulated by large combined doses of secretin and CCK-Pz, glucagon increases enzyme secretion. These findings may indicate that the inhibitory action of glucagon in the intact animal is indirect.