Canadian Anaesthetists’ Society Journal

, Volume 17, Issue 2, pp 112–118 | Cite as

Experimental studies of the central nervous system related to anaesthesia: IV. effects of pentobarbital placement in caudate nucleus

  • K. M. Leighton
  • Leonard C. Jenkins


Deep sedation results, in cats, when pentobarbital is placed in the head of caudate nucleus through precise stereotaxically implanted recording cannulae. This sedation persists in the presence of a variety of auditory stimuli, as observed by a lack of behavioural arousal and alertness and the persistence of an eeg and subcortical correlate of deactivation.

Following the application of pentobarbital into amygdala, hippocampus, ventro-postero-lateral thalamic nucleus, centro-median thalamic nucleus, and posterior hypothalamic nuclei, there was no persistent behavioural or electroencephalographic evidence of sedation in the presence of repetitive stimuli.


Pentobarbital Auditory Stimulus Caudate Nucleus Thalamic Nucleus Electrical Recording 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Moruzzi, G. &Magoun, H. W. The Brain Stem Reticular Formation and Activation of the eeg. Clin. Neurophysiol.1: 455 (1949).Google Scholar
  2. 2.
    Martin, J. T.;Faulconer, A.Jr.; &Bickford, R. G. Review Article: Electroencephalography in Anesthesiology. Anaesthesiology.20: 359 (1959).CrossRefGoogle Scholar
  3. 3.
    Jenkins, L. C.;Ling, G. M.;Foulks, J. G.; &Penrose, G. S. Experimental Central Nervous System Studies Related to Anaesthesia: Clinical Implications: I. Anaesthesia and the Brain Stem Reticular Formation. II. Effect of Reduced Sensory Inflow on Anaesthetic Requirements. Canad. Anaesth. Soc. J.10: 634 (1963).PubMedCrossRefGoogle Scholar
  4. 4.
    Yamaguchi, N.;Ling, G. M.; &Marczynski, T. J. Recruiting Responses Observed during Wakefulness and Sleep in Unanaesthetized Chronic Cats. eeg Clin. Neurophysiol.17: 246 (1964).CrossRefGoogle Scholar
  5. 5.
    Munroe, J. P.;Jenkins, L. C.; &Ling, G. M. Experimental Central Nervous System Studies Related to Anaesthesia: Clinical Implications. III. Effects of Muscle Relaxants on Sensory Inflow. Canad. Anaesth. Soc. J.13: 109 (1966).PubMedCrossRefGoogle Scholar
  6. 6.
    MacLennan, H. &York, D. H. Some Behavioural Effects of Stimulation of the Caudate Nucleus in Unrestrained Cats. Canad. J. Physiol. Pharmacol.42: 329 (1964).Google Scholar
  7. 7.
    MacLennan, H. &York, D. H. Cholinergic Mechanisms in the Caudate Nucleus. J. Physiol.187: 163 (1966).Google Scholar
  8. 8.
    Stevens, J. Stimulation of Caudate Nucleus: Behavioural Effects of Chemical and Electrical Excitation. Arch. Neurol.4: 47 (1961).Google Scholar
  9. 9.
    Kitsikis, A.;Horvath, F. E.; &Rougeul, A. Synchronized Spindle Activity Elicited in the Cortex of the Monkey by Basal Ganglia Stimulation. eeg Clin. Neurol.,25: 160 (1968).CrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1970

Authors and Affiliations

  • K. M. Leighton
  • Leonard C. Jenkins
    • 1
  1. 1.Departments of Pharmacology and Surgery (Division of Anaesthesiology)University of British ColumbiaVancouver

Personalised recommendations