Irish Journal of Medical Science

, Volume 141, Issue 1, pp 3–10 | Cite as

The intestinal mucosa in thyrotoxicosis: A light and electron microscopic assessment

  • J. A. J. Ferris


The intestinal mucosa was investigated by light and electron microscopic techniques in a group of 7 patients with thyrotoxicosis. Steatorrhoea was found in two patients and can be accounted for by other medical states. The intestinal mucosa was essentially normal in all seven cases including those with biochemical evidence of malabsorption. Urinary excretion of D-xylose and serum carotene have not been found to be reliable screening tests for malabsorption in thyrotoxicosis and possible explanations are discussed. It is concluded that thyrotoxicosisper se is not associated with structural alterations in the intestinal mucosa.


Xylose Intestinal Mucosa IRISH Journal Exocrine Pancreatic Insufficiency Mucosal Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Broitman, S. A., Bondy, D. C., Hoskins, L. C., Yachnin, I. and Zamcheck, N. 1961. Xylose absorption and urinary excretion in thyroid disease. Fed. Proc., 20, 243.Google Scholar
  2. Brown, R. B., Pendergrass, E. P. and Burdick, E. D. 1941. The gastrointestinal tract in hyperthyroidism. Surg. Gynec. Obstet., 73, 766–783.Google Scholar
  3. Cooke, P. B., Nassim, J. R. and Collins, J. 1959. The effects of thyrotoxicosis upon the metabolism of calcium, phosphorus and nitrogen. Quart. J. Med., 28, 505–529.Google Scholar
  4. Crane, C. N. and Evans, D. W. 1966. Thyrotoxic steatorrhoea. Brit. med. J., 2, 1575.PubMedCrossRefGoogle Scholar
  5. Crosby, W. H. and Kugler, H. W. 1957. Intramural biopsy of the small intestine. The intestinal biopsy capsule. Amer. J. Dig. Dis., 2, 236–241.PubMedCrossRefGoogle Scholar
  6. Ferris, J. A. J. 1968. The intestinal mucosa in disease states. (M. D. Thesis). Queen's University of Belfast.Google Scholar
  7. Hellesen, C., Friis, Th., Larsen, E. and Pock-Steen, O. Ch. 1969. Small intestinal histology, radiology and absorption. Scand. J. Gastroent., 4, 169–175.PubMedGoogle Scholar
  8. Luft, J. H. 1961. Improvements in epoxy resin embedding methods. J. biophys. biochem. Cytol., 9, 409–414.PubMedCrossRefGoogle Scholar
  9. Palade, G. E. 1952. A study of fixation for electron microscopy. J. exp. Med., 95, 285–298PubMedCrossRefGoogle Scholar
  10. Raffensperger, E. C. 1967. Hyperthyroidism and steatorrhoea in an adolescent. Amer. J. dig. Dis., 12, 6, 46–652.CrossRefGoogle Scholar
  11. Read, A. E., Gough, K. R., Bones, J. A. and McCarthy, C. F. 1962. An improvement to the Crosby peroral intestinal biopsy capsule. Lancet, 1, 894–895.CrossRefGoogle Scholar
  12. Siurala, M., Julkunen, H. and Lamberg, B. A. 1966. Gastrointestinal tract in hyperthyroidism before and after treatment. Scand. J. Gastroent., 1, 78–85.Google Scholar

Copyright information

© Springer 1972

Authors and Affiliations

  • J. A. J. Ferris
    • 1
  1. 1.Department of PathologyUniversity of Newcastle upon TyneNewcastle upon TyneUK

Personalised recommendations