The effects of anaesthesia on experimental endotoxin shock
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Summary and Conclusions
Twenty-three healthy adult dogs were subjected to endotoxin shock to evaluate the effect of anaesthesia on circulatory parameters. Fifteen dogs were anaesthetized, while the remainder were exposed to endotoxin in the awake state. The results obtained indicate that the unanaesthetized animal is able to compensate during the process of circulatory deterioration following endotoxin and is a more rugged, but less reliable, experimental model. Experiments under anaesthesia are easier to perform and yield data which are not biased by the dog’s reaction to its environment. The anaesthetized animal is thus more ideally suited for this study.
KeywordsCentral Venous Pressure Hemorrhagic Shock Awake State Endotoxin Shock Circulatory Parameter
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