Summary
In the assessment of classical haemorrhagic shock in twenty-two dogs, thirteen of them treated with Nylidrin HC1, ten survived extended episodes of arterial hypotension down to a mean arterial pressure of 40 mm.Hg. Of nine control animals (untreated), five survived the re-infusion period. In the course of our study, Nylidrin HC1 displayed two important pharmacodynamic effects:
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1.
It stimulated peripheral tissue arterial inflow, thus assisting metabolic exchange and reducing the peripheral anoxia of circulatory failure which aggravates metabolic acidosis.
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2.
It significantly increased cardiac output. Nylidrin HC1 improves myocardial contractility and reduces peripheral arterial resistance. Slight increases in cardiac rate were also noted, along with a moderate decrease in arterial blood pressure. However, neither change proved to be statistically significant. Both groups were compared during and after shock to evaluate contributions to therapy afforded by a Beta stimulatory sympathomimetic. agent.
Résumé
Les résultats de cette étude sur le choc hémorragique chez vingt-deux chiens ont démontré que dix d’entre eux, traités par l’hydrochlorure de Nylidrin (77%), ont survécu des épisodes d’hypotension artérielle sévère de 40 mm.Hg (moyenne). Du groupe témoin composé de neuf chiens, cinq ont survécu sans traitement. Dans notre 6tude, ce médicament a eu deux actions pharmaco-dynamiques importantes:
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1.
D’augmenter le débit sanguin capillaire périphérique, tout en augmentant les échanges métaboliques et diminuant l’anoxie stagnante prolongéed qui aggrave l’acidose métabolique.
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2.
II augmente le débit cardiaque de façon significative. L’hydrochlorure de Nylidrin augmente la contractilité du myocarde et diminue la resistance artérielle périphérique. L’on note aussi qu’il y a une légère augmentation du pouls cardiaque et une légère diminution de la tension artérielle moyenne; toutefois, ces changements ne se sont avérés que peu significatifs. Les deux groupes ont été comparés avant, pendant et après le choc hémorragique pour éValuer l’action thérapeutique d’un agent bêta-sympathomimétique.
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Boiteau, G.M., Dechêne, JP. Nylidrin HCL: A beta-sympathetic stimulant in the management of haemorrhagic shock. Can. Anaes. Soc. J. 13, 252–262 (1966). https://doi.org/10.1007/BF03003548
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DOI: https://doi.org/10.1007/BF03003548