Canadian Anaesthetists’ Society Journal

, Volume 14, Issue 1, pp 39–43 | Cite as

Use of alpha and beta adrenergic blocking drugs and halothane in the anaesthetic management of phaeochromocytoma

  • D. M. Gebbie
  • D. C. Finlayson


Recent work with the adrenergic blocking drugs has made it possible to block the alpha and beta effects of the catecholamines in phaeochromocytoma. This permits much wider latitude in the choice of anaesthetic techniques and agents. Four patients are presented in which these drugs were used preoperatively and during operation in combination with halothane for the management of anaesthesia.


Propranolol Halothane Succinylcholine Thiopentone Phentolamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Le phéochromocytome, bien que relativement peu fréquent, demeure d’un grand intéiêt en médecine. De récents travaux avec les médicaments bloquers adrénergiques ont abouti é la fabrication du propranolol pour bloquer les récepteurs beta. Les bloqueurs des récepteurs alpha et beta, utilisés ensemble, permettent de controler l’lrritabilité du myocarde et les effets hypertenseurs des tumeurs é catécholamines. Ils permettent également un plus grand choix des agents et des techniques anesthésiques. Ce travail illustre l’usage des bloqueurs alpha et beta, avant et au cours de l’opération, et de l’halothane dans la conduite de l’anesthésie chez quatre de ces malades. Dans tous les cas, nous avons obtenu un état stable durant toute l’opération.


  1. 1.
    Wortman, R. J. Catecholamines. New England J. Med. 273, 637, 693, 746 (1965).Google Scholar
  2. 2.
    Spector S.;Sjoerdsma, A.; &Udenfriend S. Blockade of Endoginous Norepinephrine Synthesis by Alpha Methyl-Tyrosine, an Inhibitor of Tyrosine Hydroxylose. J. Pharmacol. Exper. Therap.147: 86(1965).Google Scholar
  3. 3.
    Black, J. W.;Crowther, A. F.;Shanks, R. G.;Smith, L. H.; &Dornhurst, A. C. A New Adrenergic Beta-receptor Antagonist. Lancet.1: 1080 (1964).PubMedCrossRefGoogle Scholar
  4. 4.
    Engelman, K. &Sjoerdsma, A. Inhibition of Catecholamine Biosynthesis in Man. Circ. Res.18, 19 (Suppl. 1): 1 (1966).Google Scholar
  5. 5.
    Goldfren, A. Pheochromocytoma: Diagnosis and Anesthetic and Surgical Management. Anesthesiology.24: 462 (1963).CrossRefGoogle Scholar
  6. 6.
    Dornhorst, A. C. &Laurence, D. R. Use of Pronethalol in Phaeochrome Tumours. Brit. M. J.2: 1250 (1963).PubMedGoogle Scholar
  7. 7.
    Etsten, B. E. &Shimosato, S. Halothane Anesthesia and Catecholamine Levels in a Patient with Pheochromocytoma. Anesthesiology.26: 688 (1965).PubMedCrossRefGoogle Scholar
  8. 8.
    Hess, J. M. &Hampton, L. J. Prevention of Epinephrine-Halothane Arrhythmias by Adrenergic Beta Receptor Blockade. Anesthesiology.25: 101 (1964).CrossRefGoogle Scholar
  9. 9.
    Robertson, A. I. G. Pre- and Post-operative Care in Patients with Phaeochromocytomas. Postgrad. M. J.41: 481 (1965).PubMedCrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1967

Authors and Affiliations

  • D. M. Gebbie
    • 1
  • D. C. Finlayson
    • 1
  1. 1.Department of AnaesthesiaUniversity of Toronto and St. Michael’s HospitalToronto

Personalised recommendations