Parallel between antianxiety and cardiovascular effects of chlordiazepoxide in genetically nervous dogs

  • John L. Chapin
  • Joseph E. O. Newton


There is evidence that cardiac arrhythmias are partially of CNS origin, and that certain drugs affect arrhythmia, both positively and negatively, through CNS action. We hypothesized and confirmed that chlordiazepoxide diminished the well-established incidence of arrhythmias (A-V blocks and nodal escapes) in five nervous pointer dogs. It is known that this drug normalizes behavior and aids in the bar-pressing performance of nervous dogs. Nervous dogs tend to have low heart rates (HRs) while normals have higher HRs. Chlordiazepoxide increased HRs in our five nervous dogs, and we postulated that HR increase would be less or none in normals. This was confirmed in a later study of five normals. A further study of eight normal dogs and eight nervous dogs essentially reproduced these findings, suggesting the possibility that the slow heart rates and the behavioral abnormality have a common basis, expected to be some CNS biochemical lesion.


Chlordiazepoxide Ventricular Premature Contraction Slow Heart Rate Ventricular Ectopic Beat Chlordiazepoxide Effect 
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  1. Angel, C., Murphree, O. D. and DeLuca, D. C.: The effects of chlordiazepoxide, amphetamine and cocaine on bar-press behavior in normal and genetically nervous dogs. Dis. Nerv. Syst.35, 220–223, 1974.PubMedGoogle Scholar
  2. Dykman, R. A., Murphree, O. D. and Peters, J. E.: Like begets like: Behavioral tests, classical autonomic and motor conditioning, and operant conditioning in two strains of pointer dogs. Ann. N. Y. Acad. Sci.159, 976–1007, 1969.PubMedCrossRefGoogle Scholar
  3. Gillis, A., Thibodeaux, H. and Barr, L.: Antiarrhythmic properties of chlordiazepoxide. Circulation49, 272–282, 1974.PubMedGoogle Scholar
  4. Manning, J. W. and Cotten, M. deV.: Mechanism of cardiac arrhythmia induced by diencephalic stimulation. Am. J. Physiol.203, 1120–1124, 1962.Google Scholar
  5. Murphree, O. D.: Reduction of anxiety in genetically timid dogs. Cond. Reflex7, 170–176, 1972.PubMedGoogle Scholar
  6. Murphree, O. D.: Inheritance of human aversion and inactivity in two strains of the pointer dog. Biol. Psychiat.7, 23–29, 1973.PubMedGoogle Scholar
  7. Murphree, O. D., Dykman, R. A. and Peters, J. E.: Genetically-determined abnormal behavior in dogs: Results of behavioral tests. Cond. Reflex2, 199–205, 1967.Google Scholar
  8. Murphree, O. D., Angel, C., DeLuca, D. C., Newton, J. E. O. and Farris, H.: Nervous dogs: A partial model for psychiatric research. Lab Animal3, 16–19, 1974.Google Scholar
  9. Myers, R. D.:Handbook of Drug and Chemical Stimulation of the Brain. New York, Van Nostrand Reinhold, 1974.Google Scholar
  10. Newton, J. E. O., Murphree, O. D. and Dykman, R. A.: Sporadic transient atrioventricular block and slow heart rate in nervous pointer dogs: A genetic study. Cond. Reflex5, 75–89, 1970.PubMedGoogle Scholar
  11. Newton, J. E. O., Chapin J. L. and Murphree, O. D.: Correlations of normality and nervousness with cardiovascular functions in pointer dogs. Pav. J. Biol. Sci.11, 105–120, 1976Google Scholar

Copyright information

© Springer 1979

Authors and Affiliations

  • John L. Chapin
    • 1
  • Joseph E. O. Newton
    • 1
    • 2
  1. 1.Veterans Administration HospitalNorth Little Rock
  2. 2.Department of PsychiatryUniversity of Arkansas for Medical SciencesLittle Rock

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