Hippocampal lesions and pavlovian cardiovascular conditioning
- 13 Downloads
New Zealand albino rabbits received either sham, cortical control, or hippocampal lesions and were subjected to differential Pavlovian conditioning in which tones of different frequencies served as conditional stimuli (CSs), and a brief paraorbital electric shock train served as the unconditional stimulus. Heart rate (HR), blood pressure (BP), and electromyographic (EMG) conditional responses (CRs) were recorded. Animals with cortical and hippocampal damage or animals with cortical damage alone revealed attenuated bradycardiac CRs, but HR CRs of the former two groups did not significantly differ. BP changes were minimal; reliable differences were not obtained between CS+ and CS−. However, these changes consisted of small but reliable depressor responses, which were not affected by either cortical or hippocampal lesions. Few EMG CRs were obtained. These data, combined with those of previous experiments, suggest that forebrain structures may modulate higher level processing of stimulus information, perhaps in terms of assessing the biological significance of such stimulation.
KeywordsConditional Stimulus Blood Pressure Response Pavlovian Conditioning Hippocampal Lesion Ventral Hippocampus
Unable to display preview. Download preview PDF.
- Cohen, D. H., and MacDonald, R. L. A selective review of central neural pathways involved in cardiovascular control. In P. A. Obrist, A. H. Black, J. Brener, and L. V. Dicara (Eds.),Cardiovascular Psychophysiology: Current Issues in Response Mechanisms, Biofeedback and Methodology. New York: Aldine Publishing, 1974.Google Scholar
- Gormezano, I. Classical conditioning. In J. B. Sidowski (Ed.)Experimental Methods and Instrumentation in Psychology. New York: McGraw-Hill, 1966.Google Scholar
- Lofving, B. Cardiovascular adjustments induced from the rostral cingulate gyrus.Acta Physiologica Scandanavica, 1966,53, Suppl. 184.Google Scholar
- Powell, D. A., and Buchanan, S. L. Autonomicsomatic relationships in the rabbit (Oryctolagus Cuniculus): Effects of hippocampal lesions.Physiological Psychology, 1980,8, 455–462.Google Scholar
- Ranson, S. W., and Billingsley, P. R. Vasomotor reactions from stimulation of the floor of the fourth ventricle.American Journal of Physiology, 1961,41, 85.Google Scholar
- Schneiderman, N. The relationship between learned and unlearned cardiovascular responses. In P. A. Obrist, A. H. Black, J. Brener, and L. V. Dicara (Eds.)Cardiovascular Psychophysiology: Current Issues in Response Mechanisms, Biofeedback and Methodology. New York: Aldine Publishing, 1974.Google Scholar
- Schneiderman, N., Francis, J., Sampson, L. D., and Schwaber, J. S. CNS integration of learned cardiovascular behavior. In L. V. Dicara (Ed.)Limbic and Autonomic Nervous Systems Research. New York: Plenum Press, 1974.Google Scholar
- Solomon, P. R. A time and place for everything? Temporal processing views of hippocampal function with special reference to attention.Physiological Psychology, 1980,8, 254–261.Google Scholar
- Zanchetti, A. Hypothalamic control of circulation. In J. Stero and M. Elster (Eds.)The Nervous System in Arterial Hypertension. Springfield: Charles C Thomas, 1975.Google Scholar