Hippocampal lesions and pavlovian cardiovascular conditioning

  • Shirley L. Buchanan
  • D. A. Powell


New Zealand albino rabbits received either sham, cortical control, or hippocampal lesions and were subjected to differential Pavlovian conditioning in which tones of different frequencies served as conditional stimuli (CSs), and a brief paraorbital electric shock train served as the unconditional stimulus. Heart rate (HR), blood pressure (BP), and electromyographic (EMG) conditional responses (CRs) were recorded. Animals with cortical and hippocampal damage or animals with cortical damage alone revealed attenuated bradycardiac CRs, but HR CRs of the former two groups did not significantly differ. BP changes were minimal; reliable differences were not obtained between CS+ and CS−. However, these changes consisted of small but reliable depressor responses, which were not affected by either cortical or hippocampal lesions. Few EMG CRs were obtained. These data, combined with those of previous experiments, suggest that forebrain structures may modulate higher level processing of stimulus information, perhaps in terms of assessing the biological significance of such stimulation.


Conditional Stimulus Blood Pressure Response Pavlovian Conditioning Hippocampal Lesion Ventral Hippocampus 
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  1. Buchanan, S. L., and Powell, D. A. Divergencies in Pavlovian conditioned heart rate and eyeblink responses produced by hippocampectomy in the rabbit.Behavioral and Neural Biology, 1980,30, 20–38.CrossRefGoogle Scholar
  2. Cohen, D. H., and MacDonald, R. L. A selective review of central neural pathways involved in cardiovascular control. In P. A. Obrist, A. H. Black, J. Brener, and L. V. Dicara (Eds.),Cardiovascular Psychophysiology: Current Issues in Response Mechanisms, Biofeedback and Methodology. New York: Aldine Publishing, 1974.Google Scholar
  3. Cohen, D. H., and MacDonald, R. L. Involvement of the avian hypothalamus in defensively conditioned heart rate change.Journal of Comparative Neurology, 1976,167, 465–480.PubMedCrossRefGoogle Scholar
  4. Cohen, D. H., and Obrist, P. A. Interactions between behavior and the cardiovascular system.Circulation Research, 1975,37, 693–706.PubMedGoogle Scholar
  5. Gormezano, I. Classical conditioning. In J. B. Sidowski (Ed.)Experimental Methods and Instrumentation in Psychology. New York: McGraw-Hill, 1966.Google Scholar
  6. Hernandez, L. L., and Powell, D. A. Forebrain norepinephrine and serotonin concentration and cardiac conditioning in normal rabbits and rabbits with septal lesions.Brain Research Bulletin, 1981,6, 479–486.PubMedCrossRefGoogle Scholar
  7. Joseph, J. A., and Powell, D. A. Peripheral 6-hydroxydopamine administration in the rabbit(Oryctolagus Cuniculus): Effects on Pavlovian conditioning.Journal of Comparative and Physiological Psychology, 1980,94, 1114–1125.PubMedCrossRefGoogle Scholar
  8. Kaada, B. R. Somatomotor, autonomic, and electrocorticographic responses to electrical stimulation of “rhinecephalic” and other structures in primates, cat and dog.Acta Physiologica Scandanavica, 1951,24, 1–285.CrossRefGoogle Scholar
  9. Lanier, L. P., and Isaacson, R. L. Activity changes related to the location of lesions in the hippocampus.Behavioral Biology, 1975,13, 59–69.PubMedCrossRefGoogle Scholar
  10. Lofving, B. Cardiovascular adjustments induced from the rostral cingulate gyrus.Acta Physiologica Scandanavica, 1966,53, Suppl. 184.Google Scholar
  11. Milligan, W. L., and Richardson, A. A microprocessor (Heath ET-3400) based backup control system for laboratory experiments.Behavior Research Methods and Instrumentation, 1979,11, 314–315.CrossRefGoogle Scholar
  12. Powell, D. A., and Buchanan, S. L. Autonomicsomatic relationships in the rabbit (Oryctolagus Cuniculus): Effects of hippocampal lesions.Physiological Psychology, 1980,8, 455–462.Google Scholar
  13. Powell, D. A., and Joseph, J. A. Autonomic-somatic interaction and hippocampal theta activity.Journal of Comparative and Physiological Psychology, 1974,87, 978–986.PubMedCrossRefGoogle Scholar
  14. Powell, D. A., and Kazis, E. Blood pressure and heart rate changes accompanying classical eyeblink conditioning in the rabbit (Oryctolagus Cuniculus).Psychophysiology, 1976,13, 441–447.PubMedCrossRefGoogle Scholar
  15. Powell, D. A., Milligan, W. L., and Buchanan, S. L. Orienting and classical conditioning in the rabbit (Oryctolagus Cuniculus): Effects of septal area lesions.Physiology and Behavior, 1976,17, 955–962.PubMedCrossRefGoogle Scholar
  16. Ranson, S. W., and Billingsley, P. R. Vasomotor reactions from stimulation of the floor of the fourth ventricle.American Journal of Physiology, 1961,41, 85.Google Scholar
  17. Schneiderman, N. The relationship between learned and unlearned cardiovascular responses. In P. A. Obrist, A. H. Black, J. Brener, and L. V. Dicara (Eds.)Cardiovascular Psychophysiology: Current Issues in Response Mechanisms, Biofeedback and Methodology. New York: Aldine Publishing, 1974.Google Scholar
  18. Schneiderman, N., Francis, J., Sampson, L. D., and Schwaber, J. S. CNS integration of learned cardiovascular behavior. In L. V. Dicara (Ed.)Limbic and Autonomic Nervous Systems Research. New York: Plenum Press, 1974.Google Scholar
  19. Solomon, P. R. A time and place for everything? Temporal processing views of hippocampal function with special reference to attention.Physiological Psychology, 1980,8, 254–261.Google Scholar
  20. Zanchetti, A. Hypothalamic control of circulation. In J. Stero and M. Elster (Eds.)The Nervous System in Arterial Hypertension. Springfield: Charles C Thomas, 1975.Google Scholar

Copyright information

© Springer 1982

Authors and Affiliations

  • Shirley L. Buchanan
    • 1
    • 2
  • D. A. Powell
    • 1
    • 2
  1. 1.Neuroscience LaboratoryWm. Jennings Bryan Dorn Veterans’ HospitalColumbia
  2. 2.University of South CarolinaColumbia

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