The American Journal of Digestive Diseases

, Volume 2, Issue 10, pp 608–613 | Cite as

Experimental studies in gastric physiology in man: the mechanism of gastric evacuation after partial gastrectomy as demonstrated roentgenologically

  • Harry Shay
  • J. Gershon-Cohen
Experimental Physiology


Partial gastric resection apparently causes no basic changes in gastric evacuation. If the altered gastric chemistry which results from the resection is taken into consideration, then gastric evacuation is modified in the same way by the same agents that modify gastric-emptying of the intact stomach to a similar chemical response, except, of course, for quantitative differences. These differences appear to be due to the loss of the pyloric sphincter. The remaining gastric muscle-fibers appear to offer a substitution mechanism, but are not so efficient as was the pylorus. The response is similar to that of the intact stomach whether the test substances are ingested or are applied directly to the intestinal mucosa. The evidence also indicates that, even in a partially resected stomach, the mechanism of gastric evacuation is controlled from the intestinal side.

Since the stomach in this group was cut away from the duodenum, the intestinal effect upon gastric emptying cannot de dependent upon a reflex through the enteric plexuses. It does not however, rule out a long autonomic reflex. The data also indicate that resection of the stomach is in no real sense a “dumping operation” and that the roentgenologist in comparing gastric emptying times must take into consideration the nature of the meal used for the study.


Intestinal Mucosa Acute Appendicitis Barium Meal Hypertonic Solution Pyloric Sphincter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Billroth, T.: In a Letter to the Editor.Wien. Med. Wchnschr., 31, 162, 1881.Google Scholar
  2. 2.
    Shay, H., and Gershon-Cohen, J.: Experimental Studies in Gastric Physiology in Man. II. A Study of Pyloric Control. The Roles of Acid and Alkali.S. G. O., 58, 935, (June) 1934.Google Scholar
  3. 3.
    Johnston, C. G., and Ravdin, I. S.: The Effect of Varying Concentrations of Glucose on the Emntying Time of the Stomach, both Normal and after Various Gastric Operations.Ann. Surg., 101, 500, (Jan.) 1935.PubMedCrossRefGoogle Scholar
  4. 4.
    McCann, J. C.: Studies on the Emptying of the Stomach.Amer. J. Physiol., 89, 497, 1929.Google Scholar
  5. 5.
    Wheelon, H., and Thomas, J. E.: Observations on the Motility of the Duodenum and the Relation of the Duodenal Activity to that of the Pars Pylorica.Amer. J. Physiol., 59, 72, 1922.Google Scholar
  6. 6.
    Cole, L. G.: Motor Phenomenon of the Stomach, Pylorus, and Cap Observed Roentgenographically.Amer. J. Physiol., 42, 618, 1917.Google Scholar
  7. 7.
    Thompson, H. L.: Resection of the Pylorus. Its Effect on the Secretory and Motor Functions of the Stomach. Thesis Mayo Foundation, 1930.Google Scholar
  8. 8.
    Marbaix, O.: Le Passage Pylorique. Cellule 15, 249, 1898.Google Scholar
  9. 9.
    Ewald, C. A., and Boas, J.: Beiträge zur Physiologie und Pathologie der Verdauung.Arch. Path. u. Anat., 104, 271, 1886.CrossRefGoogle Scholar
  10. 10.
    Lintvarev, S. I.: The Role of Fats in the Passage of the Stomach Contents into the Intestine. Diss. Imperial Academy, St. Petersburg, 1901, No. 8 (In Russian).Google Scholar
  11. 11.
    Gershon-Cohen, J., and Shay, H.: Experimental Studies in Gastric Physiology in Man. III. A Study of Pyloric Control: The Role of Milk and Cream in Normal Subjects and in Those with Quiescent Duodenal Ulcer. In press.Google Scholar
  12. 12.
    Quigley, J. P., Zettleman, H. J., and Ivy, A. C.: Analysis of the Factors Involved in Gastric Motor Inhibition by Fats.Amer. J. Physiol., 108, 643, (June) 1934.Google Scholar
  13. 13.
    Quigley, J. P., and Phelps, K. R.: The Mechanism of Gastric Motor Inhitibion from Ingested Carbohydrates.Amer. J. Physiol., 109, 133, (July) 1934.Google Scholar
  14. 14.
    Ivy, A. C., and Farrell, J. I.: Contributions to Physiology of Gastric Secretion.Amer. J. Physiol., 74, 639, 1925.Google Scholar
  15. 15.
    Kosaka, T., and Lim, R. K. S.: On the Mechanism of the Inhibition of Gastric Motility by Fat. An Inhibitory Agent from the Intestinal Mucosa.Chinese J. Physiol., 7, 5, 1933.Google Scholar
  16. 16.
    Quigley, J. P., and Hallaran, W. R.: The Independence of Spontaneous Gastro-Intestinal Motility and Blood-Sugar Levels.Amer. J. Physiol., 100, 102, 1932.Google Scholar
  17. 17.
    Carnot, P. et Chassevant, A.: Modifications Subies, dans l’Estomac et le Duodénum, par les Solutions Salines, Suivant leur Concentration Moléculaire. Le Reflexe delta Régulateur du Sphincter Pylorique.Comp. Rend. de la Soc. de Biol., 58, 173, 1905.Google Scholar
  18. 18.
    Carnot, P. et Chassevant, A.: Sur le Passage Pylorique des Solutions de Glucose.Comp. Rend. de la Soc. de Biol., 58, 1069, 1905.Google Scholar
  19. 19.
    Ravdin, I. S., Johnston, C. G., and Morrison, P. J.: Comparison of Concentration of Glucose in the Stomach and Intestine After Intragastric Administration.Proc. Soc. Exp. Biol. and Med., 30, 955, 1933.Google Scholar

Copyright information

© Springer-Verlag 1935

Authors and Affiliations

  • Harry Shay
    • 1
  • J. Gershon-Cohen
    • 1
  1. 1.Philadelphia

Personalised recommendations